What is the NOAEL for Bisdisulizole disodium?
Bisdisulizole disodium has 13 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Bisdisulizole disodium
Also known as: 1H-Benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene)bis-, disodium salt, Bisimidazylate, EC 429-750-0
CAS 180898-37-7
Bisdisulizole disodium (CAS 180898-37-7) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Disodium Phenyl Dibenzimidazole Tetrasulfonate →
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Bisdisulizole disodium
CAS Number
180898-37-7
DTXSID
DTXSID001021219
Molecular Formula
C20H14N4O12S4.2Na
InChI Key
GLCJMPWWQKKJQZ-UHFFFAOYSA-L
Monoisotopic Mass
675.928645
Synonyms
1H-Benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene)bis-, disodium saltBisimidazylateEC 429-750-0
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
UV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| Z99XUY03BK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z99XUY03BK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z99XUY03BK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z99XUY03BK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=960 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >1200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 92.87 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 95.25 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 100.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 101.39 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 101.49 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 106.21 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1H-Benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene)bis-, disodium salt | 429-750-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
10% (as acid)
Category
uv_filter
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BISDISULIZOLE DISODIUM
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Bisdisulizole disodium?
Bisdisulizole disodium appears on 1 regulatory/inventory list including Europe; Personal care. Source: EPA CPDat.
Is Bisdisulizole disodium used in cosmetics?
Yes, Bisdisulizole disodium is also indexed as a cosmetic ingredient under the name Disodium Phenyl Dibenzimidazole Tetrasulfonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bisdisulizole disodium come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Bisdisulizole disodium used outside industrial chemicals?
Bisdisulizole disodium also appears in cosmetics, pharmaceutical databases.