What is the NOAEL for Phenylparaben?
Phenylparaben has 10 NOAEL studies in the database. The lowest reported value is 1.6167549548684 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phenylparaben
Also known as: EINECS 241-698-9, UNII-B15A4L4Y1J
CAS 17696-62-7
Phenylparaben (CAS 17696-62-7) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Phenylparaben is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Phenylparaben
CAS Number
17696-62-7
DTXSID
DTXSID4047882
Molecular Formula
C13H10O3
InChI Key
GJLNWLVPAHNBQN-UHFFFAOYSA-N
Monoisotopic Mass
214.062994
Synonyms
EINECS 241-698-9UNII-B15A4L4Y1J
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Biocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5.68358419534024 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 1.6167549548684 | uM | ACC | - | - | NTP_ICE_endocrine |
| 865 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| B15A4L4Y1J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B15A4L4Y1J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B15A4L4Y1J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| B15A4L4Y1J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.045 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.275 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenyl 4-hydroxybenzoate | 241-698-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184274
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Phenylparaben?
Phenylparaben appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is Phenylparaben used in cosmetics?
Yes, Phenylparaben is also indexed as a cosmetic ingredient under the name Phenylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenylparaben come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Phenylparaben have different safety status in cosmetics vs industrial chemicals?
Phenylparaben is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319).
Is Phenylparaben used outside industrial chemicals?
Phenylparaben also appears in cosmetics, pharmaceutical databases.