What is the NOAEL for 4-tert-Butylstyrene?
4-tert-Butylstyrene has 6 NOAEL studies in the database. The lowest reported value is 0.329 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-tert-Butylstyrene
Also known as: 1-tert-Butyl-4-ethenylbenzene, p-tert-Butylstyrene, 1-tert-Butyl-4-vinylbenzene, Benzene, 1-(1,1-dimethylethyl)-4-ethenyl-, 1-(1,1-Dimethylethyl)-4-ethenylbenzene (+6 more)
CAS 1746-23-2
4-tert-Butylstyrene (CAS 1746-23-2) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-tert-Butylstyrene is prohibited in EU cosmetics but has active industrial GHS classifications (H304, H315, H319, H335, H361f, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
4-tert-Butylstyrene
CAS Number
1746-23-2
DTXSID
DTXSID0022305
Molecular Formula
C12H16
InChI Key
QEDJMOONZLUIMC-UHFFFAOYSA-N
Monoisotopic Mass
160.125201
Synonyms
1-tert-Butyl-4-ethenylbenzenep-tert-Butylstyrene1-tert-Butyl-4-vinylbenzeneBenzene, 1-(1,1-dimethylethyl)-4-ethenyl-1-(1,1-Dimethylethyl)-4-ethenylbenzeneStyrene, p-tert-butyl-p-t-Butylstyrene4-t-Butylstyrene1-Ethenyl-4-tert-butylbenzene4-tert-Butyl-1-ethenylbenzeneEINECS 217-126-9
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
1 records
No specific technical function
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.329 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9PCT9CBW0V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9PCT9CBW0V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9PCT9CBW0V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9PCT9CBW0V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =100 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-tert-butylstyrene | 217-126-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183165
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 4-tert-Butylstyrene used in cosmetics?
Yes, 4-tert-Butylstyrene is also indexed as a cosmetic ingredient under the name 4-T-Butyl Styrene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-tert-Butylstyrene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-tert-Butylstyrene have different safety status in cosmetics vs industrial chemicals?
4-tert-Butylstyrene is prohibited in EU cosmetics but has active industrial GHS classifications (H304, H315, H319, H335, H361f, H400, H410).
Is 4-tert-Butylstyrene used outside industrial chemicals?
4-tert-Butylstyrene also appears in cosmetics, pharmaceutical databases.