NOAEL Data Cosmetic Ingredient

Cyclopentanone, 2-hexylidene-

CAS 17373-89-6

Cyclopentanone, 2-hexylidene- (CAS 17373-89-6) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for 2-Hexylidenecyclopentanone ⚠️ →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

Cyclopentanone, 2-hexylidene-

CAS Number

17373-89-6

DTXSID

DTXSID50864775

Molecular Formula

C11H18O

InChI Key

WZPGQHVPSKTELT-UHFFFAOYSA-N

Monoisotopic Mass

166.135765

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
Europe	European Commission	Fl@vis
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 29 of 29 studies

Value	Unit	Endpoint	Route	Species	Source
0.6375	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.75	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2.083	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
0.25	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
0.625	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
1.667	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
14	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
32.29	uM	EC3	Dermal	-	NTP_ICE_skin_sensitization
GTY12E9096	UNII	FDA UNII substance identifier	-	-	openFDA substances
GTY12E9096	UNII	FDA UNII substance identifier	-	-	openFDA substances
GTY12E9096	UNII	FDA UNII substance identifier	-	-	openFDA substances
GTY12E9096	UNII	FDA UNII substance identifier	-	-	openFDA substances
96.49	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
15.86	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
7.843	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
12	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
33.33	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
111	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
300	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
3375	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
70.76	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
506.3	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1406	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
27.75	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
421.9	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
1125	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
3.37	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 29 of 29 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Cyclopentanone, 2-hexylidene-?

Cyclopentanone, 2-hexylidene- has 29 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Cyclopentanone, 2-hexylidene-?

Cyclopentanone, 2-hexylidene- appears on 5 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product, and 2 more. Source: EPA CPDat.

Is Cyclopentanone, 2-hexylidene- used in cosmetics?

Yes, Cyclopentanone, 2-hexylidene- is also indexed as a cosmetic ingredient under the name 2-Hexylidenecyclopentanone ⚠️. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Cyclopentanone, 2-hexylidene- come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Cyclopentanone, 2-hexylidene- used outside industrial chemicals?

Cyclopentanone, 2-hexylidene- also appears in cosmetics, food safety, cannabis databases.