What is the NOAEL for Ionox 330?
Ionox 330 has 13 NOAEL studies in the database. The lowest reported value is 33.234 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ionox 330
Also known as: Phenol, 4,4',4''-[(2,4,6-trimethyl-1,3,5-benzenetriyl)tris(methylene)]tris[2,6-bis(1,1-dimethylethyl)-, 1,3,5-Tris(3,5-di-tert-butyl-4-hydroxybenzyl)mesitylene, BRN 2034522, EINECS 216-971-0, Methylene bis ethyl butyl phenol (+5 more)
CAS 1709-70-2
Ionox 330 (CAS 1709-70-2) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Ionox 330
CAS Number
1709-70-2
DTXSID
DTXSID6027428
Molecular Formula
C54H78O3
InChI Key
VSAWBBYYMBQKIK-UHFFFAOYSA-N
Monoisotopic Mass
774.595096
Synonyms
Phenol, 4,4',4''-[(2,4,6-trimethyl-1,3,5-benzenetriyl)tris(methylene)]tris[2,6-bis(1,1-dimethylethyl)-1,3,5-Tris(3,5-di-tert-butyl-4-hydroxybenzyl)mesityleneBRN 2034522EINECS 216-971-0Methylene bis ethyl butyl phenolSantoquin emulsionSantoquin mixture 62,4,6-Tri(3,5-di-tert-butyl-4-hydroxybenzyl)mesityleneUNII-51DM34B894Phenol, 4,4',4''-((2,4,6-trimethyl-1,3,5-benzenetriyl)tris(methylene))tris(2,6-bis(1,1-dimethylethyl)-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
24 records
AntioxidantStabilizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =33.234 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 51DM34B894 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51DM34B894 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51DM34B894 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 51DM34B894 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =185 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_HPVIS |
| =480 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| >960 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| >5000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| >390 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >3033.6 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,3',3'',5,5',5''-hexa-tert-butyl-α,α',α''-(mesitylene-2,4,6-triyl)tri-p-cresol | 216-971-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Frequently Asked Questions
What regulatory lists include Ionox 330?
Ionox 330 appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), Europe; plastic_additive, drinking_water; Europe; manufacturing; plastic_additive. Source: EPA CPDat.
Is Ionox 330 used in cosmetics?
Yes, Ionox 330 is also indexed as a cosmetic ingredient under the name Tris-BHT Mesitylene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ionox 330 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Ionox 330 used outside industrial chemicals?
Ionox 330 also appears in cosmetics databases.