What is the NOAEL for Neotame?
Neotame has 22 NOAEL studies in the database. The lowest reported value is 2 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Cosmetic Ingredient
Neotame
Also known as: E961, N-(N-(3,3-dimethylbutyl)-L-alpha-aspartyl)-L-phenylalanine 1-methyl ester, UNII-VJ597D52EX, N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine methyl ester
CAS 165450-17-9
Neotame (CAS 165450-17-9) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
22
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Neotame
CAS Number
165450-17-9
DTXSID
DTXSID50167950
Molecular Formula
C20H30N2O5
InChI Key
HLIAVLHNDJUHFG-HOTGVXAUSA-N
Monoisotopic Mass
378.215472
Synonyms
E961N-(N-(3,3-dimethylbutyl)-L-alpha-aspartyl)-L-phenylalanine 1-methyl esterUNII-VJ597D52EXN-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine methyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
DeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=2 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| <=2 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| <=2 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| VJ597D52EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VJ597D52EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VJ597D52EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VJ597D52EX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 200 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =200 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_EFSA |
| =200 | mg/kg bw/day | NOAEL | oral: feed | Dog | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =200 | mg/kg bw/day | NOAEL | oral: feed | Dog | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 300 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 800 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 956 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 8000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 22 of 22 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3718532
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E961 — ADI: 2 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Neotame?
Neotame appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Neotame used in cosmetics?
Yes, Neotame is also indexed as a cosmetic ingredient under the name NEOTAME. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Neotame come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Neotame used outside industrial chemicals?
Neotame also appears in cosmetics, pharmaceutical, food safety, cannabis databases.