What is the NOAEL for Silane, hexadecyltrimethoxy-?
Silane, hexadecyltrimethoxy- has 7 NOAEL studies in the database. The lowest reported value is 9.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Silane, hexadecyltrimethoxy-
Also known as: EINECS 240-464-3, UNII-975S1VH3IB
CAS 16415-12-6
Silane, hexadecyltrimethoxy- (CAS 16415-12-6) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Silane, hexadecyltrimethoxy-
CAS Number
16415-12-6
DTXSID
DTXSID9066047
Molecular Formula
C19H42O3Si
InChI Key
RSKGMYDENCAJEN-UHFFFAOYSA-N
Monoisotopic Mass
346.290322
Synonyms
EINECS 240-464-3UNII-975S1VH3IB
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
HardenerNo specific technical function
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =9.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 975S1VH3IB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 975S1VH3IB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 975S1VH3IB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 975S1VH3IB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5002 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexadecyltrimethoxysilane | 240-464-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Frequently Asked Questions
Is Silane, hexadecyltrimethoxy- used in cosmetics?
Yes, Silane, hexadecyltrimethoxy- is also indexed as a cosmetic ingredient under the name Cetyl Trimethoxysilane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Silane, hexadecyltrimethoxy- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Silane, hexadecyltrimethoxy- used outside industrial chemicals?
Silane, hexadecyltrimethoxy- also appears in cosmetics databases.