Danger GHS05GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate

Also known as: UNII-04N8KX12N6, 1-(2-Hydroxyethyl)-4,5-diaminopyrazole sulfate, 1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate (1:1), 1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate, 1-Hydroxyethyl 4,5-diamino pyrazole sulfate (+2 more)

CAS 155601-30-2

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate (CAS 155601-30-2) is a chemical substance with GHS signal word Danger; key hazard signal: H318; H317; H411. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate
CAS Number
155601-30-2
DTXSID
DTXSID20165928
Molecular Formula
C5H10N4O.H2O4S
InChI Key
IBCDZZHMNXXYAP-UHFFFAOYSA-N
Monoisotopic Mass
240.052841
Synonyms
UNII-04N8KX12N61-(2-Hydroxyethyl)-4,5-diaminopyrazole sulfate1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate (1:1)1H-Pyrazole-1-ethanol, 4,5-diamino-, sulfate1-Hydroxyethyl 4,5-diamino pyrazole sulfate4,5-Diamino-1-(2-hydroxyethyl)-1H-pyrazole sulfateColorex WP5

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2H318; H317; H411GHS05; GHS07; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
250--oral gavageSprague Dawley ratsUnifiedCodex:CIR:beta.noael_studies
250mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
300--oral gavageSprague-Dawley ratsUnifiedCodex:CIR:beta.noael_studies
300--oral gavage (maternal dosing)Sprague-Dawley ratsUnifiedCodex:CIR:beta.noael_studies
900--oral gavage (maternal dosing)Sprague-Dawley ratsUnifiedCodex:CIR:beta.noael_studies
900mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000--oral gavageSprague-Dawley ratsUnifiedCodex:CIR:beta.noael_studies
04N8KX12N6UNIIFDA UNII substance identifier--openFDA substances
04N8KX12N6UNIIFDA UNII substance identifier--openFDA substances
04N8KX12N6UNIIFDA UNII substance identifier--openFDA substances
04N8KX12N6UNIIFDA UNII substance identifier--openFDA substances
>2000mg/kg bwLD50oralRatNTP_ICE_acute_oral
800mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.02mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.02mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.02mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.02mg/kg bw/dNOAELoralratSCCS_vision_codex
250mg/kg bw/dayNOAELoralratCOSMOS_DB
=250mg/ kg body weight/dNOAELoralratCIR_vision_codex
=250-NOAELoral gavageSprague Dawley ratsCIR_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dNOAELoralratSCCS_vision_codex
=250mg/ kg body weight/dNOAELoralratCIR_vision_codex
=250-NOAELoral gavageSprague Dawley ratsCIR_vision_codex
=250mg/ kg body weight/dNOAELoralratCIR_vision_codex
=250-NOAELoral gavageSprague Dawley ratsCIR_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dNOAELoralratSCCS_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dNOAELoralratSCCS_vision_codex
=250mg/ kg body weight/dNOAELoralratCIR_vision_codex
=250-NOAELoral gavageSprague Dawley ratsCIR_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dayNOAEL--SCCS_vision_codex
=250mg/kg bw/dNOAELoralratSCCS_vision_codex
=300mg/kg body weight/dNOAELoralratCIR_vision_codex
=300-NOAELoral gavageSprague-Dawley ratsCIR_vision_codex
=300mg/kg bwNOAEL--SCCS_vision_codex
=300mg/kgNOAELoralratSCCS_vision_codex
=300mg/kg bwNOAELoralratSCCS_vision_codex
=300mg/kg bw/ dayNOAELoralratSCCS_vision_codex
=300mg/kg body weight/dNOAELoralratCIR_vision_codex
=300-NOAELoral gavageSprague-Dawley ratsCIR_vision_codex
=300mg/kg body weight/dNOAELoralratCIR_vision_codex
=300-NOAELoral gavageSprague-Dawley ratsCIR_vision_codex
=300mg/kg bwNOAEL--SCCS_vision_codex
=300mg/kgNOAELoralratSCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1-(2-hydroxyethyl)-1H-pyrazol-4,5-diyldiammoniumsulfate429-300-3ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate (CAS 155601-30-2) is classified under EU CLP Annex VI as Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H318; H317; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate has 100 NOAEL studies in the database. The lowest reported value is 0.02 mg/kg bw/d via oral in rat. Source: SCCS_vision_codex.

What regulatory lists include 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate used in cosmetics?

Yes, 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate is also indexed as a cosmetic ingredient under the name 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate have different safety status in cosmetics vs industrial chemicals?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate is classified GHS Danger (H318, H317, H411) in the chemicals database but is restricted in EU cosmetics.

Is 4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate used outside industrial chemicals?

4,5-Diamino-1-(2-hydroxyethyl)pyrazole sulfate also appears in cosmetics databases.