What is the NOAEL for N,N-Bis(2-hydroxyethyl)octylamine?
N,N-Bis(2-hydroxyethyl)octylamine has 12 NOAEL studies in the database. The lowest reported value is 61.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N-Bis(2-hydroxyethyl)octylamine
Also known as: Ethanol, 2,2'-(octylimino)bis-, Ethanol, 2,2'-(octylimino)di-, 2,2'-(Octylimino)bis[ethanol], 2,2'-(Octylimino)diethanol, Bis(2-hydroxyethyl)octylamine (+10 more)
CAS 15520-05-5
N,N-Bis(2-hydroxyethyl)octylamine (CAS 15520-05-5) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N,N-Bis(2-hydroxyethyl)octylamine is classified GHS Danger (H302, H315, H318, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
N,N-Bis(2-hydroxyethyl)octylamine
CAS Number
15520-05-5
DTXSID
DTXSID3065906
Molecular Formula
C12H27NO2
InChI Key
QZQNMMLYACBCMJ-UHFFFAOYSA-N
Monoisotopic Mass
217.204179
Synonyms
Ethanol, 2,2'-(octylimino)bis-Ethanol, 2,2'-(octylimino)di-2,2'-(Octylimino)bis[ethanol]2,2'-(Octylimino)diethanolBis(2-hydroxyethyl)octylamineDiethanoloctylamineFomaito 2E8Hetoxamine OT 2N-OctyldiethanolamineOctyldiethanolamine2,2'-(Octylimino)bisethanolETHANOL,2,2'-(OCTYLIMINO)BIS
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Surfactant (surface active agent)EmulsifierViscosity modifierCleaning agent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =61.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| HLR7HK4J1P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HLR7HK4J1P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HLR7HK4J1P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HLR7HK4J1P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~320 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =350 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =20 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~320 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-(octylimino)bisethanol | 239-555-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Frequently Asked Questions
Is N,N-Bis(2-hydroxyethyl)octylamine used in cosmetics?
Yes, N,N-Bis(2-hydroxyethyl)octylamine is also indexed as a cosmetic ingredient under the name PEG-2 CAPRYLYLAMINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Bis(2-hydroxyethyl)octylamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N-Bis(2-hydroxyethyl)octylamine have different safety status in cosmetics vs industrial chemicals?
N,N-Bis(2-hydroxyethyl)octylamine is classified GHS Danger (H302, H315, H318, H412) in the chemicals database but is allowed in EU cosmetics.
Is N,N-Bis(2-hydroxyethyl)octylamine used outside industrial chemicals?
N,N-Bis(2-hydroxyethyl)octylamine also appears in cosmetics databases.