What is the NOAEL for Iscotrizinol?
Iscotrizinol has 11 NOAEL studies in the database. The lowest reported value is 7.347 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Iscotrizinol
Also known as: Bis(2-ethylhexyl) 4,4'-({6-[4-(tert-butylcarbamoyl)anilino]-1,3,5-triazine-2,4-diyl}diazanediyl)dibenzoate, DIETHYLHEXYL BUTAMIDO TRIAZONE, 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate, Uvasorb HEB
CAS 154702-15-5
Iscotrizinol (CAS 154702-15-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for Uvasorb HEB (Diethylhexyl Butamido Triazone) →
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Iscotrizinol
CAS Number
154702-15-5
DTXSID
DTXSID40870027
Molecular Formula
C44H59N7O5
InChI Key
OSCJHTSDLYVCQC-UHFFFAOYSA-N
Monoisotopic Mass
765.457768
Synonyms
Bis(2-ethylhexyl) 4,4'-({6-[4-(tert-butylcarbamoyl)anilino]-1,3,5-triazine-2,4-diyl}diazanediyl)dibenzoateDIETHYLHEXYL BUTAMIDO TRIAZONE2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoateUvasorb HEB
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
UV stabilizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =7.347 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =10.858 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2UTZ0QC864 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2UTZ0QC864 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2UTZ0QC864 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2UTZ0QC864 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =831 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =963 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1000 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | bis(2-ethylhexyl) 4,4’-{6-[4-tert-butylcarbamoyl)anilino]-1,3,5-triazine-2,4-diyldiimino}dibenzoate | 421-450-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
sunscreen
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISCOTRIZINOL
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Iscotrizinol?
Iscotrizinol appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Iscotrizinol used in cosmetics?
Yes, Iscotrizinol is also indexed as a cosmetic ingredient under the name Uvasorb HEB (Diethylhexyl Butamido Triazone). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Iscotrizinol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Iscotrizinol used outside industrial chemicals?
Iscotrizinol also appears in cosmetics, pharmaceutical databases.