GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt

Also known as: Aluminum, hydroxybis[2,​4,​8,​10-​tetrakis(1,​1-​dimethylethyl)​-​6-​(hydroxy-​κO)​-​12H-​dibenzo[d,​g]​[1,​3,​2]​dioxaphosphocin 6-​oxidato]​-, Aluminum, hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]-, 12H-Dibenzo[d,g][1,3,2]dioxaphosphocin, aluminum deriv., Hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-(hydroxy-κO)-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]aluminum, ADK Stab NA 21E (+10 more)

CAS 151841-65-5

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt (CAS 151841-65-5) is a chemical substance; key hazard signal: H411. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate →

SOURCE noael studies public
NOAEL studies
10
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields
Name
2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt
CAS Number
151841-65-5
DTXSID
DTXSID60893238
Molecular Formula
2C29H43O4P.Al.H2O
InChI Key
IQJARXJKVIARHO-UHFFFAOYSA-K
Monoisotopic Mass
1017.571897
Synonyms
Aluminum, hydroxybis[2,​4,​8,​10-​tetrakis(1,​1-​dimethylethyl)​-​6-​(hydroxy-​κO)​-​12H-​dibenzo[d,​g]​[1,​3,​2]​dioxaphosphocin 6-​oxidato]​-Aluminum, hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]-12H-Dibenzo[d,g][1,3,2]dioxaphosphocin, aluminum deriv.Hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-(hydroxy-κO)-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]aluminumADK Stab NA 21EAluminium hydroxy bis[2,2'-methylene-bis(4,6-di-tert-butylphenyl) phosphate]Aluminum hydroxybis[2,2'-methylenebis[4,6-di(tert-butyl)phenyl]phosphate]Aluminum methylenebis(2,4-di-tert-butyl-benzyloxy)phosphateBis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1,2,3]dioxaphosphocin-6-oxide) aluminum hydroxide saltBis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1,2,3]dioxaphosphocin-6-oxide)aluminum hydroxideBis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxide) aluminum hydroxideBis[2,2'-methylenebis(4,6-di-tert-butylphenyl) phosphate] aluminum hydroxide salt

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Aquatic Chronic 2H411GHS09-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies
ValueUnitEndpointRouteSpeciesSource
=3.5mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
32S296KGN1UNIIFDA UNII substance identifier--openFDA substances
32S296KGN1UNIIFDA UNII substance identifier--openFDA substances
32S296KGN1UNIIFDA UNII substance identifier--openFDA substances
32S296KGN1UNIIFDA UNII substance identifier--openFDA substances
150mg/kg bw/dayLOAELoralratCOSMOS_DB
50mg/kg bw/dayNOAELoralratCOSMOS_DB
>=50mg/kg bw/dayNOAELoralDogToxValDB_ECHA_IUCLID
=50mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID
=80mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 10 of 10 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredHydroxy aluminium bis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1.3.2]dioxaphosphocin-6-oxide)430-650-4ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Rheology Modifier
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt?

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt (CAS 151841-65-5) is classified under EU CLP Annex VI as Aquatic Chronic 2. Hazard statements: H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt?

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt has 10 NOAEL studies in the database. The lowest reported value is 3.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt?

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.

Is 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt used in cosmetics?

Yes, 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt is also indexed as a cosmetic ingredient under the name Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt have different safety status in cosmetics vs industrial chemicals?

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt is prohibited in EU cosmetics but has active industrial GHS classifications (H411).

Is 2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt used outside industrial chemicals?

2,2-Methylenebis(4,6-di-tert-butylphenyl) phosphate aluminum hydroxide salt also appears in cosmetics databases.