Also known as: Hydroquinone monomethyl ether, p-Methoxyphenol, EINECS 205-769-8, Mono methyl ether hydroquinone, Monomethyl ether hydroquinone (+3 more)
CAS 150-76-5
4-Methoxyphenol (CAS 150-76-5) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319; H317. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Eye Irrit. 2; Skin Sens. 1 | H302; H319; H317 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the skin. This may result in depigmentation. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| ACGIH | TWA | 5 mg/m³ [1992] | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Europe | European Commission | Fl@vis |
| Europe; Personal care; restricted | European Commission | CosIng |
| pharmaceutical | US International Trade Commission | CPCat |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 36 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 6HT8U7K3AM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6HT8U7K3AM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6HT8U7K3AM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6HT8U7K3AM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =225 | mg/kg bw/day | LOAEL | oral | Hamster | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =375 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =40 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =40 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_HPVIS |
| =100 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 19 of 19 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Mequinol | 205-769-8 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →4-Methoxyphenol (CAS 150-76-5) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H302; H319; H317. Source: EU CLP Annex VI (ECHA).
4-Methoxyphenol has 19 NOAEL studies in the database. The lowest reported value is 3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
4-Methoxyphenol appears on 8 regulatory/inventory lists including Indirect additives food contact (10/2018), Cons electronics mech appliances and machinery; detected; Europe, Europe, and 5 more. Source: EPA CPDat.
Occupational exposure limits for 4-Methoxyphenol are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 4-Methoxyphenol is also indexed as a cosmetic ingredient under the name P-HYDROXYANISOLE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
4-Methoxyphenol also appears in cosmetics, pharmaceutical, cannabis databases.