NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

4-Aminobenzoic acid

Also known as: 1-Amino-4-carboxybenzene, BRN 0471605, Caswell No. 033B, EINECS 205-753-0, EPA Pesticide Chemical Code 233300 (+15 more)

CAS 150-13-0

4-Aminobenzoic acid (CAS 150-13-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH.

View cosmetic safety profile for PABA →

SOURCE noael studies public
NOAEL studies
67
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
4-Aminobenzoic acid
CAS Number
150-13-0
DTXSID
DTXSID6024466
Molecular Formula
C7H7NO2
InChI Key
ALYNCZNDIQEVRV-UHFFFAOYSA-N
Monoisotopic Mass
137.047678
Synonyms
1-Amino-4-carboxybenzeneBRN 0471605Caswell No. 033BEINECS 205-753-0EPA Pesticide Chemical Code 233300Super Shade by CoppertoneUNII-TL2TJE8QTX4-AminobenzoateAcido p-aminobenzoicoAcidum paraminobenzoicumAmbenAminobenzoate

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable198716, Sup 7

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records
UV stabilizerFlavouring and nutrientNo specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
banned; Europe; Personal careEuropean CommissionCosIng
inert_ingredient; non_food_use; PesticidesEPACPCat
Canada; pharmaceuticalDrugBankDrugBank
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Europe; Personal careDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 67 studies
ValueUnitEndpointRouteSpeciesSource
0.1%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
108--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
108--oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
>200ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
>1000ug/mLCV75Dermal-NTP_ICE_skin_sensitization
-uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=10.58mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
1%Depletion CysDermal-NTP_ICE_skin_sensitization
1.4%Depletion CysDermal-NTP_ICE_skin_sensitization
3.9%Depletion CysDermal-NTP_ICE_skin_sensitization
4.6%Depletion CysDermal-NTP_ICE_skin_sensitization
5.9%Depletion CysDermal-NTP_ICE_skin_sensitization
10.6%Depletion CysDermal-NTP_ICE_skin_sensitization
10.7%Depletion CysDermal-NTP_ICE_skin_sensitization
-%Depletion LysDermal-NTP_ICE_skin_sensitization
0.1%Depletion LysDermal-NTP_ICE_skin_sensitization
0.4%Depletion LysDermal-NTP_ICE_skin_sensitization
0.5%Depletion LysDermal-NTP_ICE_skin_sensitization
0.6%Depletion LysDermal-NTP_ICE_skin_sensitization
0.7%Depletion LysDermal-NTP_ICE_skin_sensitization
0.9%Depletion LysDermal-NTP_ICE_skin_sensitization
0.35%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
0.45%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
1.05%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
2.3%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
2.35%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
2.4%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
3.2%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
5.55%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
5.6%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
>2000uMEC1.5Dermal-NTP_ICE_skin_sensitization
TL2TJE8QTXUNIIFDA UNII substance identifier--openFDA substances
TL2TJE8QTXUNIIFDA UNII substance identifier--openFDA substances
TL2TJE8QTXUNIIFDA UNII substance identifier--openFDA substances
TL2TJE8QTXUNIIFDA UNII substance identifier--openFDA substances
0.766fractionFu-HumanNTP_ICE_adme_parameters
3IARC groupIARC carcinogenicity classification--IARC Monographs
3IARC groupIARC carcinogenicity classification--IARC Monographs
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP_ICE_cancer
>2400uMIC50Dermal-NTP_ICE_skin_sensitization
1.107ratioImaxDermal-NTP_ICE_skin_sensitization
1.21ratioImaxDermal-NTP_ICE_skin_sensitization
1.23ratioImaxDermal-NTP_ICE_skin_sensitization
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
15520ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
-unitlessModel Score--NTP_ICE_endocrine
=0.1%NOAELoralratSCCS_vision_codex
=0.1%NOAELoralratSCCS_vision_codex

Showing 50 of 67 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered4-aminobenzoic acid205-753-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/0937/0520 June 2006safeup to 5%Photocontact allergic reactions reported; skin sensitisation risk; declining use in favour of alternatives; no mutagenic/carcinogenic/teratogenic risk identified; possible thyroid disrupting activity (not confirmed)

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
II/167
Category
UV Filters
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL AMINOBENZOIC ACID
ChEMBL Phase
-1
Adverse Events
715
Bioactivity
12
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 4-Aminobenzoic acid?

4-Aminobenzoic acid has 67 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 4-Aminobenzoic acid?

4-Aminobenzoic acid appears on 5 regulatory/inventory lists including banned; Europe; Personal care, inert_ingredient; non_food_use; Pesticides, Canada; pharmaceutical, and 2 more. Source: EPA CPDat.

Is 4-Aminobenzoic acid a carcinogen according to IARC?

4-Aminobenzoic acid is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 4-Aminobenzoic acid used in cosmetics?

Yes, 4-Aminobenzoic acid is also indexed as a cosmetic ingredient under the name PABA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Aminobenzoic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-Aminobenzoic acid used outside industrial chemicals?

4-Aminobenzoic acid also appears in cosmetics, pharmaceutical databases.