What is the NOAEL for L-Proline?
L-Proline has 6 NOAEL studies in the database. The lowest reported value is 488.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Proline
Also known as: EINECS 205-702-2, FEMA No. 3319, FEMA Number 3319, PRO, UNII-9DLQ4CIU6V (+12 more)
CAS 147-85-3
L-Proline (CAS 147-85-3) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
L-Proline
CAS Number
147-85-3
DTXSID
DTXSID5044021
Molecular Formula
C5H9NO2
InChI Key
ONIBWKKTOPOVIA-BYPYZUCNSA-N
Monoisotopic Mass
115.063329
Synonyms
EINECS 205-702-2FEMA No. 3319FEMA Number 3319PROUNII-9DLQ4CIU6V(-)-2-Pyrrolidinecarboxylate(2S)-pyrrolidine-2-carboxylic acid(S)-(-)-Pyrrolidine-2-carboxylate(S)-(-)-Pyrrolidine-2-carboxylic acid(S)-2-Pyrralidinecarboxylate(S)-2-Pyrralidinecarboxylic acid(S)-2-Pyrrolidinecarboxylate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
15 records
Anti-static agentSoftener and conditionerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =488.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9DLQ4CIU6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9DLQ4CIU6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9DLQ4CIU6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9DLQ4CIU6V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-proline | 205-702-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PROLINE
ChEMBL Phase
2
Adverse Events
5
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Proline?
L-Proline appears on 6 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical, and 3 more. Source: EPA CPDat.
Is L-Proline used in cosmetics?
Yes, L-Proline is also indexed as a cosmetic ingredient under the name L-Proline. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Proline come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Proline used outside industrial chemicals?
L-Proline also appears in cosmetics, pharmaceutical, food safety, cannabis databases.