NOAEL Data Cosmetic Ingredient

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol

CAS 1444596-49-9

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol (CAS 1444596-49-9) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, SCCS.

View cosmetic safety profile for HC Red No. 18 →

SOURCE noael studies public
NOAEL studies
51
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol
CAS Number
1444596-49-9
DTXSID
DTXSID801372937
Molecular Formula
C9H7ClN4OS2
InChI Key
XQNTVGDQOPVBIP-OUKQBFOZSA-N
Monoisotopic Mass
285.9749809

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 51 studies
ValueUnitEndpointRouteSpeciesSource
=0.013mg/kg bwNOAELoralratSCCS_vision_codex
=0.013mg/kg bwNOAELoralratSCCS_vision_codex
=0.013mg/kg bwNOAELoralratSCCS_vision_codex
=0.013mg/kg bwNOAELoralratSCCS_vision_codex
=0.022mg/kg bwNOAELoralratSCCS_vision_codex
=0.022mg/kg bwNOAELoralratSCCS_vision_codex
=0.022mg/kg bwNOAELoralratSCCS_vision_codex
=0.022mg/kg bwNOAELoralratSCCS_vision_codex
=2.31mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.31mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.31mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.31mg/kg bw/dNOAELoralratSCCS_vision_codex
=3mg/kg bw/dayNOAELoralratSCCS_vision_codex
=3mg/kg/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dNOAELoralratSCCS_vision_codex
=3mg/kg bw/dayNOAELoralratSCCS_vision_codex
=3mg/kg/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dNOAELoralratSCCS_vision_codex
=3mg/kg bw/dayNOAELoralratSCCS_vision_codex
=3mg/kg/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dNOAELoralratSCCS_vision_codex
=3mg/kg bw/dayNOAELoralratSCCS_vision_codex
=3mg/kg/dayNOAEL-ratSCCS_vision_codex
=3mg/kg bw/dNOAELoralratSCCS_vision_codex
=50mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=50mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=50mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=50mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=77%NOAELoralratSCCS_vision_codex
=77%NOAELoralratSCCS_vision_codex
=77%NOAELoralratSCCS_vision_codex
=77%NOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=100mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.013mg/kg bwdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=2.31mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=3mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg bw/daydevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/daydevelopmental toxicity-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/daydevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/daydevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg bw/daygenotoxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg bw/daygenotoxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg bw/daygenotoxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
77%irritationoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg/dayrepeated dose toxicity-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
3mg/kg/dayrepeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
77%repeated dose toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 51 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1673/2422 January 2025safe with restrictions1.5% oxidative / 0.5% non-oxidativesensitization
SCCS/1569/1516 March 2016insufficient data-purity inadequately quantified

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol?

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol has 51 NOAEL studies in the database. The lowest reported value is 0.013 mg/kg bw via oral in rat. Source: SCCS_vision_codex.

Is 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol used in cosmetics?

Yes, 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol is also indexed as a cosmetic ingredient under the name HC Red No. 18. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol come from?

Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol used outside industrial chemicals?

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol also appears in cosmetics databases.