Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Oxalic acid

Also known as: Ethanedioic acid, Aktisal, Aquisal, DeerClean, NSC 132055 (+15 more)

CAS 144-62-7

Oxalic acid (CAS 144-62-7) is a chemical substance with GHS signal word Warning; key hazard signal: H312; H302. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for OXALIC ACID →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Oxalic acid

CAS Number

144-62-7

DTXSID

DTXSID0025816

Molecular Formula

C2H2O4

InChI Key

MUBZPKHOEPUJKR-UHFFFAOYSA-N

Monoisotopic Mass

89.995309

Synonyms

Ethanedioic acidAktisalAquisalDeerCleanNSC 1320554-02-00-01819BRN 0385686Caswell No. 625EINECS 205-634-3EPA Pesticide Chemical Code 009601NCI-C55209Oxiric acid

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 ; Acute Tox. 4	H312; H302	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The substance may cause effects on the calcium balance after ingestion. Exposure at high levels could cause death.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis. Exposure may result in kidney stones, slow-healing ulcers and black finger nails.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Serious local effects by all routes of exposure.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 8 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	1 mg/m³	-	1	N
NIOSH	TWA	1 mg/m³	-	1	N
NIOSH	STEL	2 mg/m³	-	2	N
ACGIH	TWA	1 mg/m³ [2014]	-	1	N
ACGIH	STEL	2 mg/m³ [2014]	-	2	N
CAL/OSHA	TWA	1 mg/m³	-	1	N
CAL/OSHA	STEL	2 mg/m³	-	2	N
NIOSH	IDLH	500 mg/m³	-	500	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 14 records

Chelating agentpH regulating agentTanning agents not otherwise specifiedCleaning agentFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
pharmaceutical	US International Trade Commission	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Cleaning products and household care; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 49 of 49 studies

Value	Unit	Endpoint	Route	Species	Source
25.7483810718647	uM	AC50	-	-	NTP_ICE_endocrine
18.5653394227728	uM	ACC	-	-	NTP_ICE_endocrine
310.33	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
>630.238	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
1000	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
=3.11	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
0.9	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
-0.9	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
-	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
0.45	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
717.2	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
0.000011	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.000011	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.000011	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.000011	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
6.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
6.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
6.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
6.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
15	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
15	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
15	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
15	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
9E7R5L6H31	UNII	FDA UNII substance identifier	-	-	openFDA substances
9E7R5L6H31	UNII	FDA UNII substance identifier	-	-	openFDA substances
9E7R5L6H31	UNII	FDA UNII substance identifier	-	-	openFDA substances
9E7R5L6H31	UNII	FDA UNII substance identifier	-	-	openFDA substances
>2000	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
2.7	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
=7500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1900	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~5000	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1.88	mg/mL	LOEL	oral	Mouse	ToxValDB_ECOTOX
=2.5	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=5	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=8	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=80.6	mg/L	LOEL	oral	Mouse	ToxValDB_ECOTOX
=340	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=450	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1780	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1980	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.00766	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0225	unitless	Model Score	-	-	NTP_ICE_endocrine
=162	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
<=1000	ppm	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
~2000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.2	%	NOEL	oral	Mouse	ToxValDB_ECOTOX
=0.9	mg/mL	NOEL	oral	Mouse	ToxValDB_ECOTOX

Showing 49 of 49 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Oxalic acid	205-634-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

III/3

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL OXALIC ACID

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Oxalic acid?

Oxalic acid (CAS 144-62-7) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H312; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Oxalic acid?

Oxalic acid has 49 NOAEL studies in the database. The lowest reported value is -0.9 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Oxalic acid?

Oxalic acid appears on 13 regulatory/inventory lists including IFRA Transparency, pharmaceutical, drinking_water; Europe; manufacturing; plastic_additive, and 10 more. Source: EPA CPDat.

What are the occupational exposure limits for Oxalic acid?

Occupational exposure limits for Oxalic acid are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Oxalic acid used in cosmetics?

Yes, Oxalic acid is also indexed as a cosmetic ingredient under the name OXALIC ACID. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Oxalic acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Oxalic acid used outside industrial chemicals?

Oxalic acid also appears in cosmetics, pharmaceutical, cannabis databases.