What is the NOAEL for 2,2,4-Trimethyl-1,3-pentanediol?
2,2,4-Trimethyl-1,3-pentanediol has 6 NOAEL studies in the database. The lowest reported value is 6.61 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2,4-Trimethyl-1,3-pentanediol
Also known as: 4-01-00-02604, BRN 1698098, Caswell No. 893, EINECS 205-619-1, EPA Pesticide Chemical Code 041002 (+1 more)
CAS 144-19-4
2,2,4-Trimethyl-1,3-pentanediol (CAS 144-19-4) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Trimethyl-1,3-Pentanediol →
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
2,2,4-Trimethyl-1,3-pentanediol
CAS Number
144-19-4
DTXSID
DTXSID8027113
Molecular Formula
C8H18O2
InChI Key
JCTXKRPTIMZBJT-UHFFFAOYSA-N
Monoisotopic Mass
146.13068
Synonyms
4-01-00-02604BRN 1698098Caswell No. 893EINECS 205-619-1EPA Pesticide Chemical Code 041002UNII-WT1X081P0L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Solvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.61 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| WT1X081P0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WT1X081P0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WT1X081P0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WT1X081P0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2,4-trimethylpentane-1,3-diol | 205-619-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184961
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,2,4-Trimethyl-1,3-pentanediol?
2,2,4-Trimethyl-1,3-pentanediol appears on 5 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Toys and children's products, CEDI, Indirect additives food contact (10/2018), and 2 more. Source: EPA CPDat.
Is 2,2,4-Trimethyl-1,3-pentanediol used in cosmetics?
Yes, 2,2,4-Trimethyl-1,3-pentanediol is also indexed as a cosmetic ingredient under the name Trimethyl-1,3-Pentanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2,4-Trimethyl-1,3-pentanediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,2,4-Trimethyl-1,3-pentanediol used outside industrial chemicals?
2,2,4-Trimethyl-1,3-pentanediol also appears in cosmetics, pharmaceutical databases.