What is the NOAEL for N-(6-Aminohexyl)hexane-1,6-diamine?
N-(6-Aminohexyl)hexane-1,6-diamine has 6 NOAEL studies in the database. The lowest reported value is 0.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N-(6-Aminohexyl)hexane-1,6-diamine
Also known as: Bis(6-aminohexyl)amine, Bis(hexamethylene)triamine, 1,13-Diamino-7-azatridecane, 6,6'-Diaminodihexylamine, Dihexylenetriamine (+4 more)
CAS 143-23-7
N-(6-Aminohexyl)hexane-1,6-diamine (CAS 143-23-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for BIS(HEXAMETHYLENE)TRIAMINE →
Cross-Vertical Regulatory Divergence
N-(6-Aminohexyl)hexane-1,6-diamine is classified GHS Danger (H302, H312, H311, H314, H318, H335, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
N-(6-Aminohexyl)hexane-1,6-diamine
CAS Number
143-23-7
DTXSID
DTXSID4027109
Molecular Formula
C12H29N3
InChI Key
MRNZSTMRDWRNNR-UHFFFAOYSA-N
Monoisotopic Mass
215.236148
Synonyms
Bis(6-aminohexyl)amineBis(hexamethylene)triamine1,13-Diamino-7-azatridecane6,6'-DiaminodihexylamineDihexylenetriamineEINECS 205-593-1NSC 92231N-(Aminohexyl)-1,6-hexanediamineUNII-BID902UF5V
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
SolventNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| BID902UF5V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BID902UF5V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BID902UF5V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BID902UF5V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =450 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 7-azatridecane-1,13-diamine | 205-593-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL318516
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include N-(6-Aminohexyl)hexane-1,6-diamine?
N-(6-Aminohexyl)hexane-1,6-diamine appears on 3 regulatory/inventory lists including Canada; pharmaceutical, CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is N-(6-Aminohexyl)hexane-1,6-diamine used in cosmetics?
Yes, N-(6-Aminohexyl)hexane-1,6-diamine is also indexed as a cosmetic ingredient under the name BIS(HEXAMETHYLENE)TRIAMINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-(6-Aminohexyl)hexane-1,6-diamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-(6-Aminohexyl)hexane-1,6-diamine have different safety status in cosmetics vs industrial chemicals?
N-(6-Aminohexyl)hexane-1,6-diamine is classified GHS Danger (H302, H312, H311, H314, H318, H335, H412) in the chemicals database but is allowed in EU cosmetics.
Is N-(6-Aminohexyl)hexane-1,6-diamine used outside industrial chemicals?
N-(6-Aminohexyl)hexane-1,6-diamine also appears in cosmetics, pharmaceutical databases.