What is the NOAEL for Hexanoic acid?
Hexanoic acid has 25 NOAEL studies in the database. The lowest reported value is 17.632 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexanoic acid
Also known as: 4-02-00-00917, BRN 0773837, EINECS 205-550-7, FEMA No. 2559, Hexacid 698 (+15 more)
CAS 142-62-1
Hexanoic acid (CAS 142-62-1) is a chemical substance. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Hexanoic acid is classified GHS Danger (H311, H314, H318, H332) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
20
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Hexanoic acid
CAS Number
142-62-1
DTXSID
DTXSID7021607
Molecular Formula
C6H12O2
InChI Key
FUZZWVXGSFPDMH-UHFFFAOYSA-N
Monoisotopic Mass
116.08373
Synonyms
4-02-00-00917BRN 0773837EINECS 205-550-7FEMA No. 2559Hexacid 698Kyselina kapronovaUNII-1F8SN134MX1-Hexanoate1-Pentanecarboxylate6:0ButylacetateC6:0
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and through the skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
14 records
Surfactant (surface active agent)DeodorizerEmulsifierFragranceCleaning agentpH regulating agentSolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
20 records
| List | Keyword | Source |
|---|---|---|
| air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 95.3 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 133.4 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 165 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =17.632 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1F8SN134MX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1F8SN134MX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1F8SN134MX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1F8SN134MX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =61762.3 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 1 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 1.4 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 1.3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 1.5 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3.6 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 8.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 20.8 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 1.9 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.4 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.5 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexanoic acid | 205-550-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HEXANOATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Hexanoic acid?
Hexanoic acid appears on 16 regulatory/inventory lists including air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe, air; detected; emissions; Europe; Home maintenance - caulk/sealant, pharmaceutical, and 13 more. Source: EPA CPDat.
Is Hexanoic acid used in cosmetics?
Yes, Hexanoic acid is also indexed as a cosmetic ingredient under the name Caproic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexanoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Hexanoic acid have different safety status in cosmetics vs industrial chemicals?
Hexanoic acid is classified GHS Danger (H311, H314, H318, H332) in the chemicals database but is allowed in EU cosmetics.
Is Hexanoic acid used outside industrial chemicals?
Hexanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.