What is the NOAEL for 2,6-Diaminopyridine?
2,6-Diaminopyridine has 4 NOAEL studies in the database. The lowest reported value is K89AB8CKG6 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2,6-Diaminopyridine
Also known as: 5-22-11-00255, BRN 0108513, EINECS 205-507-2, UNII-K89AB8CKG6
CAS 141-86-6
2,6-Diaminopyridine (CAS 141-86-6) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
Cross-Vertical Regulatory Divergence
2,6-Diaminopyridine is prohibited in EU cosmetics at max 0.3% but has active industrial GHS classifications (H301, H315, H317, H319, H335, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
2,6-Diaminopyridine
CAS Number
141-86-6
DTXSID
DTXSID0040127
Molecular Formula
C5H7N3
InChI Key
VHNQIURBCCNWDN-UHFFFAOYSA-N
Monoisotopic Mass
109.063997
Synonyms
5-22-11-00255BRN 0108513EINECS 205-507-2UNII-K89AB8CKG6
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| K89AB8CKG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K89AB8CKG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K89AB8CKG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K89AB8CKG6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1490/12 | 26 February 2013 | insufficient data | - | insufficient characterisation data; strong sensitiser (EC3 ~0.09%) |
| SCCS/1462/12 | 27 March 2012 | insufficient data | - | insufficient characterisation and quantification data |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
0.3%
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL339234
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,6-Diaminopyridine?
2,6-Diaminopyridine appears on 2 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care; restricted. Source: EPA CPDat.
Is 2,6-Diaminopyridine used in cosmetics?
Yes, 2,6-Diaminopyridine is also indexed as a cosmetic ingredient under the name 2,6-Diaminopyridine ⚠️. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,6-Diaminopyridine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,6-Diaminopyridine have different safety status in cosmetics vs industrial chemicals?
2,6-Diaminopyridine is prohibited in EU cosmetics at max 0.3% but has active industrial GHS classifications (H301, H315, H317, H319, H335, H411).
Is 2,6-Diaminopyridine used outside industrial chemicals?
2,6-Diaminopyridine also appears in cosmetics, pharmaceutical databases.