Danger GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Ethyl acetate

Also known as: Caswell No. 429, EINECS 205-500-4, EPA Pesticide Chemical Code 044003, Ethyl ester, FEMA No. 2414 (+15 more)

CAS 141-78-6

Ethyl acetate (CAS 141-78-6) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H336; H319. Key regulatory status: REACH registered, 47 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Ethyl Acetate →

Cross-Vertical Regulatory Divergence

Ethyl acetate is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Ethyl acetate

CAS Number

141-78-6

DTXSID

DTXSID1022001

Molecular Formula

C4H8O2

InChI Key

XEKOWRVHYACXOJ-UHFFFAOYSA-N

Monoisotopic Mass

88.052429

Synonyms

Caswell No. 429EINECS 205-500-4EPA Pesticide Chemical Code 044003Ethyl esterFEMA No. 2414RCRA waste number U112AethylacetatEthylacetaatEthyle (acetate d')Ethylester kyseliny octoveOctan etyluUNII-76845O8NMZ

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 2; STOT SE 3; Eye Irrit. 2	H225; H336; H319	GHS02; GHS07	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Highly flammable liquid and vapour May cause drowsiness or dizziness
Short-term Effects	The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	400 ppm (1400 mg/m³)	400	1400	N
NIOSH	TWA	400 ppm (1400 mg/m³)	400	1400	N
ACGIH	TWA	400 ppm [1979]	400	-	N
CAL/OSHA	TWA	400 ppm (1400 mg/m³)	400	1400	N
NIOSH	IDLH	2000 ppm	2000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceSolventFlavouring and nutrientAdhesion/cohesion promoter

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 47 records

List	Keyword	Source
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies; Europe	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected	Elsevier	CPCat
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions	Elsevier	CPCat
air; detected; emissions; Personal care	Elsevier	CPCat
air; Cleaning products and household care; detected; emissions	Elsevier	CPCat
air; Cleaning products and household care - air freshener; detected; emissions	Elsevier	CPCat
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - oven - oven cleaner; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - liniment	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - liniment	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - body adhesive	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
Arts and crafts/Office supplies; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
pharmaceutical	US International Trade Commission	CPCat
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 49 of 49 studies

Value	Unit	Endpoint	Route	Species	Source
<=25	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
<=25	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=25	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=734	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
18	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
76845O8NMZ	UNII	FDA UNII substance identifier	-	-	openFDA substances
76845O8NMZ	UNII	FDA UNII substance identifier	-	-	openFDA substances
76845O8NMZ	UNII	FDA UNII substance identifier	-	-	openFDA substances
76845O8NMZ	UNII	FDA UNII substance identifier	-	-	openFDA substances
2	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
6480	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
0.29	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
5.762	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>21.6077	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
200	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=2140.5	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=4493	mg/kg bw/day	LEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
=36000	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=57700	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=72070.7	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=360	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_DOE_Wildlife_Benchmarks
=3600	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=3600	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
=1261.24	mg/m3	LOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2017.98	mg/m3	LOEC	inhalation	Mouse	ToxValDB_ECHA_IUCLID
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
=2702.65	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=90	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_DOE_Wildlife_Benchmarks
=900	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=900	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=900	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=5405.3	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>57656.6	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=209	mg/m3	NOAEL (HEC)	inhalation	Rat	ToxValDB_PPRTV_(CPHEA)
=216	mg/kg bw/day	NOAEL (HED)	oral	Rat	ToxValDB_PPRTV_(CPHEA)
=1081.06	mg/m3	NOEC	inhalation	Mouse	ToxValDB_ECHA_IUCLID
=1261.24	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2702.65	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>5405.3	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=900	mg/kg/day	NOEL	oral	-	EPA_IRIS_iris_rfd_systems.csv
52	%	Plateau level	Ocular	-	NTP_ICE_eye_irritation
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization
=0.07	mg/m3	RfC	inhalation	Human	ToxValDB_Pennsylvania_DEP_ToxValues
=0.7	mg/m3	RfC (provisional)	inhalation	Human	ToxValDB_PPRTV_(CPHEA)
=0.9	mg/kg bw/day	RfD	oral	Human	ToxValDB_IRIS
=0.9	mg/kg/day	RfD	oral	-	EPA_IRIS_iris_rfd_systems.csv
=0.7	mg/kg bw/day	RfD (provisional)	oral	Human	ToxValDB_PPRTV_(CPHEA)

Showing 49 of 49 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Ethyl acetate	205-500-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ETHYL ACETATE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-25 mg/kg bw (1967) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ethyl acetate?

Ethyl acetate (CAS 141-78-6) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H336; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ethyl acetate?

Ethyl acetate has 49 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Ethyl acetate?

Ethyl acetate appears on 33 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe, Arts and crafts/Office supplies; Europe, inert_ingredient; Pesticides, and 30 more. Source: EPA CPDat.

What are the occupational exposure limits for Ethyl acetate?

Occupational exposure limits for Ethyl acetate are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ethyl acetate used in cosmetics?

Yes, Ethyl acetate is also indexed as a cosmetic ingredient under the name Ethyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ethyl acetate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Ethyl acetate have different safety status in cosmetics vs industrial chemicals?

Ethyl acetate is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.

Is Ethyl acetate used outside industrial chemicals?

Ethyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.