What is the NOAEL for Ferrous fumarate?
Ferrous fumarate has 15 NOAEL studies in the database. The lowest reported value is 0.822 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ferrous fumarate
Also known as: EINECS 205-447-7, Erco-Fer, Ercoferro, Feostat, Feroton (+15 more)
CAS 141-01-5
Ferrous fumarate (CAS 141-01-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Ferrous fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
15
SOURCE
Chemical inventory jurisdictions
Regulatory lists
5
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Ferrous fumarate
CAS Number
141-01-5
DTXSID
DTXSID7047148
Molecular Formula
C4H4O4.Fe
InChI Key
PMVSDNDAUGGCCE-TYYBGVCCSA-L
Monoisotopic Mass
171.945895
Synonyms
EINECS 205-447-7Erco-FerErcoferroFeostatFerotonFerrofumeFerronatFerroneFerrotempFersamalFumaferFumar-F
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.822 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| R5L488RY0Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R5L488RY0Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R5L488RY0Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R5L488RY0Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.8 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 16 | mg/kg bw/day | NOAEL | oral | horse | COSMOS DB |
| 50 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 152 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =160 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =400 | mg/kg bw/day | NOAEL | oral | Guinea Pig | ECHA |
| 800 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 1369 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Iron(II) fumarate | 205-447-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ferrous fumarate
ChEMBL Phase
Not listed
Adverse Events
2027
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ferrous fumarate?
Ferrous fumarate appears on 5 regulatory/inventory lists including Europe; supplements, Europe; food_additive; supplements, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is Ferrous fumarate used in cosmetics?
Yes, Ferrous fumarate is also indexed as a cosmetic ingredient under the name Ferrous Fumarate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ferrous fumarate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Ferrous fumarate have different safety status in cosmetics vs industrial chemicals?
Ferrous fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H412).
Is Ferrous fumarate used outside industrial chemicals?
Ferrous fumarate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.