What is the NOAEL for Cinnamyl isovalerate?
Cinnamyl isovalerate has 10 NOAEL studies in the database. The lowest reported value is 5JHK9Y2XRM UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Cinnamyl isovalerate
Also known as: Cinnamyl 3-methyl butyrate, Cinnamyl 3-methylbutanoate, 3-Methylbutanoic acid 3-phenyl-2-propenyl ester, 3-Phenylallyl 3-methylbutanoate, 3-Phenyl-2-propenyl 3-methylbutanoate (+12 more)
CAS 140-27-2
Cinnamyl isovalerate (CAS 140-27-2) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
23 fields
Name
Cinnamyl isovalerate
CAS Number
140-27-2
DTXSID
DTXSID7059694
Molecular Formula
C14H18O2
InChI Key
FOCMOGKCPPTERB-UHFFFAOYSA-N
Monoisotopic Mass
218.13068
Synonyms
Cinnamyl 3-methyl butyrateCinnamyl 3-methylbutanoate3-Methylbutanoic acid 3-phenyl-2-propenyl ester3-Phenylallyl 3-methylbutanoate3-Phenyl-2-propenyl 3-methylbutanoateButanoic acid, 3-methyl-, 3-phenyl-2-propenyl esterButanoic acid, 3-methyl-, 3-phenyl-2-propen-1-yl ester3-Phenyl-2-propen-1-yl isovalerateCinnamyl alcohol, isovalerateBRN 3201227Cinnamyl isovalerianateEINECS 205-407-9
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
6 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5JHK9Y2XRM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5JHK9Y2XRM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5JHK9Y2XRM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5JHK9Y2XRM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =275 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =275 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =275 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL4162391
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Cinnamyl isovalerate?
Cinnamyl isovalerate appears on 5 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Cinnamyl isovalerate used in cosmetics?
Yes, Cinnamyl isovalerate is also indexed as a cosmetic ingredient under the name Cinnamyl Isovalerate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cinnamyl isovalerate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Cinnamyl isovalerate used outside industrial chemicals?
Cinnamyl isovalerate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.