What is the NOAEL for 2-Ethyl-3,5-dimethylpyrazine?
2-Ethyl-3,5-dimethylpyrazine has 6 NOAEL studies in the database. The lowest reported value is R182EY5L8C UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2-Ethyl-3,5-dimethylpyrazine
Also known as: Pyrazine, 2-ethyl-3,5-dimethyl-, 2,6-Dimethyl-3-ethylpyrazine, 3,5-Dimethyl-2-ethylpyrazine, 3-Ethyl-2,6-dimethylpyrazine, EC No.: 237-694-1 (+4 more)
CAS 13925-07-0
2-Ethyl-3,5-dimethylpyrazine (CAS 13925-07-0) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for 2-Ethyl-3,5-Dimethylpyrazine →
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-Ethyl-3,5-dimethylpyrazine
CAS Number
13925-07-0
DTXSID
DTXSID7065679
Molecular Formula
C8H12N2
InChI Key
JZBCTZLGKSYRSF-UHFFFAOYSA-N
Monoisotopic Mass
136.100048
Synonyms
Pyrazine, 2-ethyl-3,5-dimethyl-2,6-Dimethyl-3-ethylpyrazine3,5-Dimethyl-2-ethylpyrazine3-Ethyl-2,6-dimethylpyrazineEC No.: 237-694-15-23-05-00440BRN 0636984EINECS 237-694-1UNII-R182EY5L8C
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| R182EY5L8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R182EY5L8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R182EY5L8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R182EY5L8C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =456 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 11.1 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 6 of 6 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL328856
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Ethyl-3,5-dimethylpyrazine?
2-Ethyl-3,5-dimethylpyrazine appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2-Ethyl-3,5-dimethylpyrazine used in cosmetics?
Yes, 2-Ethyl-3,5-dimethylpyrazine is also indexed as a cosmetic ingredient under the name 2-Ethyl-3,5-Dimethylpyrazine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethyl-3,5-dimethylpyrazine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Ethyl-3,5-dimethylpyrazine used outside industrial chemicals?
2-Ethyl-3,5-dimethylpyrazine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.