What is the NOAEL for Sodium cyclamate?
Sodium cyclamate has 11 NOAEL studies in the database. The lowest reported value is 1I6F42RME1 UNII. Source: openFDA substances.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Sodium cyclamate
Also known as: Cyclamate, sodium, Assurgrin feinsuss, Assurgrin vollsuss, Cyclamate, sodium salt, Cyclamic acid sodium salt (+15 more)
CAS 139-05-9
Sodium cyclamate (CAS 139-05-9) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Sodium cyclamate
CAS Number
139-05-9
DTXSID
DTXSID6020355
Molecular Formula
C6H13NO3S.Na
InChI Key
UDIPTWFVPPPURJ-UHFFFAOYSA-M
Synonyms
Cyclamate, sodiumAssurgrin feinsussAssurgrin vollsussCyclamate, sodium saltCyclamic acid sodium saltCyclohexanesulfamic acid, sodium saltCyclohexanesulphamic acid, monosodium saltCyclohexylsulfamic acid, sodium saltCyclohexylsulphamate sodiumCyclohexylsulphamic acid, monosodium saltEINECS 205-348-9Monosodium cyclohexylsulfamate
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | Sup 7, 73 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
DeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1I6F42RME1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I6F42RME1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I6F42RME1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1I6F42RME1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =1280 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2000 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =1000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium cyclamate | 205-348-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM CYCLAMATE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 7 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Sodium cyclamate?
Sodium cyclamate appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Sodium cyclamate a carcinogen according to IARC?
Sodium cyclamate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Sodium cyclamate used in cosmetics?
Yes, Sodium cyclamate is also indexed as a cosmetic ingredient under the name Sodium Cyclamate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium cyclamate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Sodium cyclamate used outside industrial chemicals?
Sodium cyclamate also appears in cosmetics, pharmaceutical, food safety databases.