What is the NOAEL for Shikimic acid?
Shikimic acid has 9 NOAEL studies in the database. The lowest reported value is 29MS2WI2NU UNII. Source: openFDA substances.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Shikimic acid
Also known as: Bracken fern toxic component, 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta))-, EINECS 205-334-2, 3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid, UNII-29MS2WI2NU (+8 more)
CAS 138-59-0
Shikimic acid (CAS 138-59-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, ECHA REACH.
Cross-Vertical Regulatory Divergence
Shikimic acid is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Shikimic acid
CAS Number
138-59-0
DTXSID
DTXSID4032039
Molecular Formula
C7H10O5
InChI Key
JXOHGGNKMLTUBP-HSUXUTPPSA-N
Monoisotopic Mass
174.052823
Synonyms
Bracken fern toxic component1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta))-EINECS 205-334-23,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acidUNII-29MS2WI2NU(-)-Shikimate(3R,4S,5R)-3,4,5-trihydroxycyclohexene-1-carboxylic acid3alpha,4alpha,5beta-trihydroxy-1-cyclohexene-1-carboxylic acidL-ShikimateShikimateSkikimateSkikimic acid
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 40, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
DeodorizerSoftener and conditionerAnti-dandruff
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29MS2WI2NU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29MS2WI2NU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29MS2WI2NU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29MS2WI2NU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (3R,4S,5R)-3,4,5-trihydroxycyclohex-1-enecarboxylic acid | 205-334-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SHIKIMIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Shikimic acid?
Shikimic acid appears on 1 regulatory/inventory list including pharmaceutical. Source: EPA CPDat.
Is Shikimic acid a carcinogen according to IARC?
Shikimic acid is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Shikimic acid used in cosmetics?
Yes, Shikimic acid is also indexed as a cosmetic ingredient under the name Shikimic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Shikimic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Shikimic acid have different safety status in cosmetics vs industrial chemicals?
Shikimic acid is classified GHS Danger (H318) in the chemicals database but is allowed in EU cosmetics.
Is Shikimic acid used outside industrial chemicals?
Shikimic acid also appears in cosmetics, pharmaceutical databases.