What is the NOAEL for Ascorbyl palmitate?
Ascorbyl palmitate has 11 NOAEL studies in the database. The lowest reported value is 1.25 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ascorbyl palmitate
Also known as: 6-O-Palmitoylascorbic acid, L-Ascorbic acid, 6-hexadecanoate, 5-18-05-00031, L-Ascorbic acid 6-palmitate, Ascorbyl 6-hexadecanoate, L- (+8 more)
CAS 137-66-6
Ascorbyl palmitate (CAS 137-66-6) is a chemical substance. Key regulatory status: REACH registered, 19 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
19
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Ascorbyl palmitate
CAS Number
137-66-6
DTXSID
DTXSID3041611
Molecular Formula
C22H38O7
InChI Key
QAQJMLQRFWZOBN-LAUBAEHRSA-N
Monoisotopic Mass
414.261754
Synonyms
6-O-Palmitoylascorbic acidL-Ascorbic acid, 6-hexadecanoate5-18-05-00031L-Ascorbic acid 6-palmitateAscorbyl 6-hexadecanoate, L-1-Ascorbyl palmitateAscorbyl palmitic acidBRN 0096552EINECS 205-305-4Palmitic acid, ester with ascorbic acid6-O-Palmitoyl ascorbate6-Palmitoyl-L-ascorbic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
AntioxidantDeodorizerFragrancePreservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
19 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=1.25 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| QN83US2B0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QN83US2B0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QN83US2B0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QN83US2B0N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 6-O-palmitoylascorbic acid | 205-305-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
1%
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ASCORBYL PALMITATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E304 — ADI: 1.25 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ascorbyl palmitate?
Ascorbyl palmitate appears on 13 regulatory/inventory lists including IFRA Transparency, consumer_product, inert_ingredient; Pesticides, and 10 more. Source: EPA CPDat.
Is Ascorbyl palmitate used in cosmetics?
Yes, Ascorbyl palmitate is also indexed as a cosmetic ingredient under the name Ascorbyl Palmitate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ascorbyl palmitate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ascorbyl palmitate used outside industrial chemicals?
Ascorbyl palmitate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.