NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-1-butanol

Also known as: 4-01-00-01666, BRN 1718810, dl-sec-Butyl carbinol, EINECS 205-289-9, EINECS 252-163-4 (+14 more)

CAS 137-32-6

2-Methyl-1-butanol (CAS 137-32-6) is a chemical substance. Key regulatory status: REACH registered, 16 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for 2-Methylbutanol →

Cross-Vertical Regulatory Divergence

2-Methyl-1-butanol is classified GHS Danger (H226, H315, H318, H332, H335, H319) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

2-Methyl-1-butanol

CAS Number

137-32-6

DTXSID

DTXSID5027069

Molecular Formula

C5H12O

InChI Key

QPRQEDXDYOZYLA-UHFFFAOYSA-N

Monoisotopic Mass

88.088815

Synonyms

4-01-00-01666BRN 1718810dl-sec-Butyl carbinolEINECS 205-289-9EINECS 252-163-42-Methyl butanol-1UNII-7VTJ239ASU(+/-)-2-Methyl-1-butanol(1)-2-Methylbutan-1-ol(S)-(-)-2-Methyl-1-butanol(S)-2-Methylbutan-1-ol2-Methyl-(.+/-.)-1-Butanol

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

FragranceFlavouring and nutrientSolvent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 16 records

List	Keyword	Source
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Europe	European Commission	Fl@vis
IFRA Transparency	IFRA	IFRA
consumer_product	P&G	Proctor & Gamble
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
=73.16	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
7VTJ239ASU	UNII	FDA UNII substance identifier	-	-	openFDA substances
7VTJ239ASU	UNII	FDA UNII substance identifier	-	-	openFDA substances
7VTJ239ASU	UNII	FDA UNII substance identifier	-	-	openFDA substances
7VTJ239ASU	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-methylbutan-1-ol	205-289-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL451923

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Methyl-1-butanol?

2-Methyl-1-butanol has 5 NOAEL studies in the database. The lowest reported value is 73.16 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Methyl-1-butanol?

2-Methyl-1-butanol appears on 7 regulatory/inventory lists including active_ingredient; Pesticides, air; detected; emissions; Europe; Other direct contact consumer goods, detected; Europe; Other direct contact consumer goods, and 4 more. Source: EPA CPDat.

Is 2-Methyl-1-butanol used in cosmetics?

Yes, 2-Methyl-1-butanol is also indexed as a cosmetic ingredient under the name 2-Methylbutanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-1-butanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-1-butanol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-1-butanol is classified GHS Danger (H226, H315, H318, H332, H335, H319) in the chemicals database but is allowed in EU cosmetics.

Is 2-Methyl-1-butanol used outside industrial chemicals?

2-Methyl-1-butanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.