What is the NOAEL for 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1)?
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) has 7 NOAEL studies in the database. The lowest reported value is 9L2QOQ6WFH UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1)
Also known as: 4,5-Diamino-1-n-hexyl-1H-pyrazole hemisulfate
CAS 1361000-03-4
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) (CAS 1361000-03-4) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH.
View cosmetic safety profile for 1-Hexyl 4,5-Diamino Pyrazole Sulfate →
Cross-Vertical Regulatory Divergence
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) is classified GHS Danger (H301, H331, H312, H317, H372, H411) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
7 fields
Name
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1)
CAS Number
1361000-03-4
DTXSID
DTXSID401020932
Molecular Formula
2C9H18N4.H2O4S
InChI Key
YXIPRERMSJCCGC-UHFFFAOYSA-N
Monoisotopic Mass
462.273673
Synonyms
4,5-Diamino-1-n-hexyl-1H-pyrazole hemisulfate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9L2QOQ6WFH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L2QOQ6WFH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L2QOQ6WFH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L2QOQ6WFH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =26 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~8 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-hexyl-1H-pyrazole-4,5-diamine sulfate (2:1) | 696-231-5 | ECHA overview → |
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1562/15 | 15 December 2015 | safe | 1.0% | moderate skin sensitiser |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
Frequently Asked Questions
What regulatory lists include 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1)?
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Is 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) used in cosmetics?
Yes, 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) is also indexed as a cosmetic ingredient under the name 1-Hexyl 4,5-Diamino Pyrazole Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) have different safety status in cosmetics vs industrial chemicals?
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) is classified GHS Danger (H301, H331, H312, H317, H372, H411) in the chemicals database but is restricted in EU cosmetics.
Is 1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) used outside industrial chemicals?
1H-Pyrazole-4,5-diamine, 1-hexyl-, sulfate (2:1) also appears in cosmetics databases.