NOAEL Data REACH Registered Cosmetic Ingredient

Alumina

Also known as: Aluminum oxide (Al2O3), aluminum-oxide, CAP 2, A1-0104 T 3/16'', A1-1404 T 3/16'' (+15 more)

CAS 1344-28-1

Alumina (CAS 1344-28-1) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Alumina →

Cross-Vertical Regulatory Divergence

Alumina is classified GHS Danger (H335, H372) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

Alumina

CAS Number

1344-28-1

DTXSID

DTXSID2041593

Synonyms

Aluminum oxide (Al2O3)aluminum-oxideCAP 2A1-0104 T 3/16''A1-1404 T 3/16''A1-3438 T 1/8''A1-3945 E 1/16''A1-3980 T 5/32''A1-4028 T 3/16''A1-4126 E 1/16''F 360G 0

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Short-term Effects	Inhalation of high concentrations of dust may cause irritation of the eyes and respiratory tract.
Long-term Effects	The substance may have effects on the central nervous system.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	15 mg/m³ (total dust), 5 mg/m³ (respirable fraction)	-	15	N
ACGIH	TWA	1 mg/m³ (respirable particulate matter) [2007]	-	1	N
CAL/OSHA	TWA	10 mg/m³ (total dust), 5 mg/m³ (respirable fraction)	-	10	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FillerAbrasiveAbsorbentOpaciferViscosity modifierAnti-caking agentAnti-static agentPigmentStabilizing agentSurface modifierBinder

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records

List	Keyword	Source
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
Cleaning products and household care - oven - oven cleaner; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
inert_ingredient; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 9 of 9 studies

Value	Unit	Endpoint	Route	Species	Source
=3	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
=15.63	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
LMI26O6933	UNII	FDA UNII substance identifier	-	-	openFDA substances
LMI26O6933	UNII	FDA UNII substance identifier	-	-	openFDA substances
LMI26O6933	UNII	FDA UNII substance identifier	-	-	openFDA substances
LMI26O6933	UNII	FDA UNII substance identifier	-	-	openFDA substances
>0.888	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>2.3	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
7.6	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation

Showing 9 of 9 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Aluminium oxide	215-691-6	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Aluminum oxide (fibrous forms)	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed ALUMINIUM OXIDE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Alumina?

Alumina has 9 NOAEL studies in the database. The lowest reported value is 3 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.

What regulatory lists include Alumina?

Alumina appears on 9 regulatory/inventory lists including Europe; Personal care, drinking_water; Europe; manufacturing; plastic_additive, Cleaning products and household care - oven - oven cleaner; Europe, and 6 more. Source: EPA CPDat.

What are the occupational exposure limits for Alumina?

Occupational exposure limits for Alumina are set by OSHA, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Alumina used in cosmetics?

Yes, Alumina is also indexed as a cosmetic ingredient under the name Alumina. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Alumina come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Alumina have different safety status in cosmetics vs industrial chemicals?

Alumina is classified GHS Danger (H335, H372) in the chemicals database but is allowed in EU cosmetics.

Is Alumina used outside industrial chemicals?

Alumina also appears in cosmetics, pharmaceutical, cannabis databases.