What is the GHS hazard classification for DEET?
DEET (CAS 134-62-3) is classified under EU CLP Annex VI as Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H315; H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
Cosmetic Ingredient
DEET
Also known as: N,N-Diethyl-m-toluamide, N,N-Diethyl-3-methylbenzamide, N,N-Diethyl-meta-toluamide, DEET (N,N-diethyl-meta-toluamide), BRN 2046711 (+9 more)
CAS 134-62-3
DEET (CAS 134-62-3) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H315; H319. Key regulatory status: 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
DEET is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
84
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
DEET
CAS Number
134-62-3
DTXSID
DTXSID2021995
Molecular Formula
C12H17NO
InChI Key
MMOXZBCLCQITDF-UHFFFAOYSA-N
Monoisotopic Mass
191.131014
Synonyms
N,N-Diethyl-m-toluamideN,N-Diethyl-3-methylbenzamideN,N-Diethyl-meta-toluamideDEET (N,N-diethyl-meta-toluamide)BRN 2046711Caswell No. 346EINECS 205-149-7EPA Pesticide Chemical Code 080301MGK diethyltoluamideRepper-DETDiethyltoluamidumDietiltoluamida
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2 | H302; H315; H319 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
HumectantNo specific technical functionBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; ground_water; MN Chemical Screening | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 84 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 52.94 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 492.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 504.2 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 3.797 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 6.7 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 6.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 2 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA classification | Dermal | Rat | NTP_ICE_acute_dermal |
| =3 | Unitless | EPA classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| FB0C1XZV4Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FB0C1XZV4Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FB0C1XZV4Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FB0C1XZV4Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.3559 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 4 | unitless | GHS Classification | Inhalation | - | NTP_ICE_acute_inhalation |
| =4 | Unitless | GHS classification | oral | Rat (Female) | NTP_ICE_acute_oral |
| 5 | unitless | GHS classification | Dermal | Rat | NTP_ICE_acute_dermal |
| 1914 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.07 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.076 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| >2.3 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 5.862 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 5.95 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 6.047 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1950 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg | LD50 | Dermal | Rat | NTP_ICE_acute_dermal |
| =2000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3000 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =90 | mg/kg bw/day | LEL | oral | rat | ToxRefDB_ToxRefDB_v3_pod.csv |
| =90 | mg/kg bw/day | LEL | oral | rat | ToxRefDB_ToxRefDB_v3_pod.csv |
| =250 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Crl:COBS CD) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =304 | mg/kg bw/day | LEL | oral | Hamster | ToxValDB_ToxRefDB |
| =304 | mg/kg bw/day | LEL | oral | hamster (golden syrian; golden syrian) | ToxRefDB_ToxRefDB_v3_pod.csv |
| >325 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_ToxRefDB |
| >325 | mg/kg bw/day | LEL | oral | rabbit (new zealand white; New Zealand White) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =400 | mg/kg bw/day | LEL | oral | Dog | ToxValDB_ToxRefDB |
| =400 | mg/kg bw/day | LEL | oral | dog (beagle; beagle) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =500 | mg/kg bw/day | LEL | oral | rat (sprague-dawley; sprague-dawley) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =636 | mg/kg bw/day | LEL | oral | Hamster | ToxValDB_ToxRefDB |
| =636 | mg/kg bw/day | LEL | oral | hamster (golden syrian; golden syrian) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =750 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =750 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague-Dawley COBS CD (SD) BR) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =1000 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
Showing 50 of 84 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIETHYLTOLUAMIDE
ChEMBL Phase
3
Adverse Events
72
Bioactivity
3
Frequently Asked Questions
What is the NOAEL for DEET?
DEET has 84 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
What regulatory lists include DEET?
DEET appears on 8 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), detected; MN Chemical Screening; surface_water, detected; drinking_water; MN Chemical Screening, and 5 more. Source: EPA CPDat.
Is DEET used in cosmetics?
Yes, DEET is also indexed as a cosmetic ingredient under the name Diethyl Toluamide (DEET). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for DEET come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does DEET have different safety status in cosmetics vs industrial chemicals?
DEET is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319).
Is DEET used outside industrial chemicals?
DEET also appears in cosmetics, pharmaceutical databases.