What is the NOAEL for 3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one?
3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one has 5 NOAEL studies in the database. The lowest reported value is EWW1JFM977 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one
Also known as: 2(4H)-Benzofuranone, 5,6,7,7a-tetrahydro-3,6-dimethyl-, (-)-Dehydroxymenthofuran oxide, 5,6,7,7a-Tetrahydro-3,6-dimethyl-2(4H)-benzofuranone, Dehydroxymenthofuranoxide, Dehydroxymenthofurolactone (+10 more)
CAS 13341-72-5
3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (CAS 13341-72-5) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for TETRAHYDRO-DIMETHYL-BENZOFURAN-2-ONE →
SOURCE
NOAEL studies
NOAEL studies
5
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one
CAS Number
13341-72-5
DTXSID
DTXSID90884593
Molecular Formula
C10H14O2
InChI Key
VUVQBYIJRDUVHT-UHFFFAOYSA-N
Monoisotopic Mass
166.09938
Synonyms
2(4H)-Benzofuranone, 5,6,7,7a-tetrahydro-3,6-dimethyl-(-)-Dehydroxymenthofuran oxide5,6,7,7a-Tetrahydro-3,6-dimethyl-2(4H)-benzofuranoneDehydroxymenthofuranoxideDehydroxymenthofurolactoneMenthalactoneMint furanoneΔ1,α-Cyclohexaneacetic acid, 2-hydroxy-α,4-dimethyl-, γ-lactoneEC No.: 236-390-6EINECS 236-390-6MintlactoneFEMA No. 3764
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| EWW1JFM977 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EWW1JFM977 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EWW1JFM977 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EWW1JFM977 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =125 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB EPA TSCA 8e |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include 3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one?
3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one used in cosmetics?
Yes, 3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one is also indexed as a cosmetic ingredient under the name TETRAHYDRO-DIMETHYL-BENZOFURAN-2-ONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is 3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one used outside industrial chemicals?
3,6-Dimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one also appears in cosmetics, food safety databases.