NOAEL Data REACH Registered Cosmetic Ingredient

Tris(methylphenyl) phosphate

Also known as: Tritolyl phosphate, Phosphoric acid, tris(methylphenyl) ester, Caswell No. 884, EINECS 215-548-8, EPA Pesticide Chemical Code 083401 (+13 more)

CAS 1330-78-5

Tris(methylphenyl) phosphate (CAS 1330-78-5) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Tricresyl Phosphate →

Cross-Vertical Regulatory Divergence

Tris(methylphenyl) phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H361, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

Tris(methylphenyl) phosphate

CAS Number

1330-78-5

DTXSID

DTXSID4021391

Synonyms

Tritolyl phosphatePhosphoric acid, tris(methylphenyl) esterCaswell No. 884EINECS 215-548-8EPA Pesticide Chemical Code 083401Flexol Plasticizer TCPNCI-C61041Phosflex 179AThiorthocresyl phosphatePhosphate de tricresyleTricresilfosfatiTricresylfosfaten

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records

PlasticizerFlame retardant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
banned; Europe; Personal care	European Commission	CosIng
children	Vermont Department of Health	State of Vermont
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 40 of 40 studies

Value	Unit	Endpoint	Route	Species	Source
41.6901401012661	uM	AC50	-	-	NTP_ICE_endocrine
95.4400224840921	uM	ACC	-	-	NTP_ICE_endocrine
=2.12	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB_ATSDR_MRLs
=3.72	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB_ATSDR_MRLs
=0.18	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
512641US16	UNII	FDA UNII substance identifier	-	-	openFDA substances
512641US16	UNII	FDA UNII substance identifier	-	-	openFDA substances
512641US16	UNII	FDA UNII substance identifier	-	-	openFDA substances
512641US16	UNII	FDA UNII substance identifier	-	-	openFDA substances
=7	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=7	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=8	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=8	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=0.5	% diet	LOAEL	oral	Rat	ToxValDB_HPVIS
=20	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=62.5	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=2000	ppm	LOEL	oral	Mouse	ToxValDB_ECOTOX
=0.02	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs
=0.04	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0171	unitless	Model Score	-	-	NTP_ICE_endocrine
>-	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=1000	mg/m3	NEL	inhalation	Rat	ToxValDB_EPA_TSCA_8e
=0.1	% diet	NOAEL	oral	Rat	ToxValDB_HPVIS
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HESS
=300	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=2000	mg/kg bw/day	NOAEL	oral	Chicken	ToxValDB_ECHA_IUCLID
=0.1	%	NOEL	oral	Mouse	ToxValDB_ECOTOX
=0.1	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc110
=0.1	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc110
=0.2	%	NOEL	oral	Mouse	ToxValDB_ECOTOX
=30	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
<40	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
<50	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
=65	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
<86.4	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
250	ppm	Top dose	Gavage; Dosed feed	Mouse	NTP_ICE_cancer
600	ppm	Top dose	Gavage; Dosed feed	Rat	NTP_ICE_cancer

Showing 40 of 40 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Tris(methylphenyl) phosphate	809-930-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for Tris(methylphenyl) phosphate?

Tris(methylphenyl) phosphate has 40 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Tris(methylphenyl) phosphate?

Tris(methylphenyl) phosphate appears on 4 regulatory/inventory lists including active_ingredient; Pesticides, banned; Europe; Personal care, children, and 1 more. Source: EPA CPDat.

Is Tris(methylphenyl) phosphate used in cosmetics?

Yes, Tris(methylphenyl) phosphate is also indexed as a cosmetic ingredient under the name Tricresyl Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Tris(methylphenyl) phosphate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Tris(methylphenyl) phosphate have different safety status in cosmetics vs industrial chemicals?

Tris(methylphenyl) phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H361, H400, H410).

Is Tris(methylphenyl) phosphate used outside industrial chemicals?

Tris(methylphenyl) phosphate also appears in cosmetics databases.