NOAEL Data Cosmetic Ingredient

2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid

CAS 1321-57-9

2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid (CAS 1321-57-9) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Isopropyl Citrate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid

CAS Number

1321-57-9

DTXSID

DTXSID40862624

Molecular Formula

C9H14O7

InChI Key

SKHXHUZZFVMERR-UHFFFAOYSA-N

Monoisotopic Mass

234.073953

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

SolventPlasticizerChelating agentProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 8 of 8 studies

Value	Unit	Endpoint	Route	Species	Source
GL3533UI0R	UNII	FDA UNII substance identifier	-	-	openFDA substances
GL3533UI0R	UNII	FDA UNII substance identifier	-	-	openFDA substances
GL3533UI0R	UNII	FDA UNII substance identifier	-	-	openFDA substances
GL3533UI0R	UNII	FDA UNII substance identifier	-	-	openFDA substances
15	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
530	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
2550	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS_DB
2650	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB

Showing 8 of 8 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid?

2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid has 8 NOAEL studies in the database. The lowest reported value is GL3533UI0R UNII. Source: openFDA substances.

What regulatory lists include 2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid?

2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid appears on 1 regulatory/inventory list including food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is 2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid used in cosmetics?

Yes, 2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid is also indexed as a cosmetic ingredient under the name Isopropyl Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid used outside industrial chemicals?

2-Hydroxy-2-{2-oxo-2-[(propan-2-yl)oxy]ethyl}butanedioic acid also appears in cosmetics, food safety databases.