NOAEL Data REACH Registered Cosmetic Ingredient

(Hydroxyethyl)urea

Also known as: EINECS 215-304-0

CAS 1320-51-0

(Hydroxyethyl)urea (CAS 1320-51-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Hydroxyethyl Urea →

SOURCE noael studies public
NOAEL studies
3
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 4 fields
Name
(Hydroxyethyl)urea
CAS Number
1320-51-0
DTXSID
DTXSID4051663
Synonyms
EINECS 215-304-0

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 13 records
HumectantSoftener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 3 of 3 studies
ValueUnitEndpointRouteSpeciesSource
=146.67mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
>2000mg/kg bwLD50oralRatNTP_ICE_acute_oral
>3473mg/kg bwLD50oralRatNTP_ICE_acute_oral

Showing 3 of 3 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered(hydroxyethyl)urea215-304-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the chemical is to be used in rinse-off or leave-on cosmetic products at concentrations >8%. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectants
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for (Hydroxyethyl)urea?

(Hydroxyethyl)urea has 3 NOAEL studies in the database. The lowest reported value is 146.67 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include (Hydroxyethyl)urea?

(Hydroxyethyl)urea appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.

Is (Hydroxyethyl)urea used in cosmetics?

Yes, (Hydroxyethyl)urea is also indexed as a cosmetic ingredient under the name Hydroxyethyl Urea. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (Hydroxyethyl)urea come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is (Hydroxyethyl)urea used outside industrial chemicals?

(Hydroxyethyl)urea also appears in cosmetics databases.