What is the NOAEL for Dibenzothiophene?
Dibenzothiophene has 15 NOAEL studies in the database. The lowest reported value is 1.04 mg/kg bw/day via oral in Rat. Source: ToxValDB_PPRTV_(CPHEA).
NOAEL Data
IARC Group 3
Cosmetic Ingredient
Dibenzothiophene
Also known as: (1,1'-Biphenyl)-2,2'-diyl sulfide, Dibenzo(b,d)thiophene, EINECS 205-072-9, UNII-Z3D4AJ1R48, alpha-thiafluorene
CAS 132-65-0
Dibenzothiophene (CAS 132-65-0) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
Cross-Vertical Regulatory Divergence
Dibenzothiophene is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H371, H311, H315, H331, H332, H400, H410).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Dibenzothiophene
CAS Number
132-65-0
DTXSID
DTXSID0047741
Molecular Formula
C12H8S
InChI Key
IYYZUPMFVPLQIF-UHFFFAOYSA-N
Monoisotopic Mass
184.034671
Synonyms
(1,1'-Biphenyl)-2,2'-diyl sulfideDibenzo(b,d)thiopheneEINECS 205-072-9UNII-Z3D4AJ1R48alpha-thiafluorene
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 2011 | 103 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 35.5673705358343 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 34.6369174121674 | uM | ACC | - | - | NTP_ICE_endocrine |
| =1.04 | mg/kg bw/day | BMDL (10 HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| Z3D4AJ1R48 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z3D4AJ1R48 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z3D4AJ1R48 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z3D4AJ1R48 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00373 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =3 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| =0.003 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 15 of 15 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIBENZOTHIOPHENE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
Is Dibenzothiophene a carcinogen according to IARC?
Dibenzothiophene is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 2011). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Dibenzothiophene used in cosmetics?
Yes, Dibenzothiophene is also indexed as a cosmetic ingredient under the name Dibenzothiophene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dibenzothiophene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dibenzothiophene have different safety status in cosmetics vs industrial chemicals?
Dibenzothiophene is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H371, H311, H315, H331, H332, H400, H410).
Is Dibenzothiophene used outside industrial chemicals?
Dibenzothiophene also appears in cosmetics, pharmaceutical databases.