What is the NOAEL for Cresol?
Cresol has 20 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Rat. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Cresol
Also known as: Tricresol, Phenol, methyl-, Cresylol, Cresols, Kresol (+15 more)
CAS 1319-77-3
Cresol (CAS 1319-77-3) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, EPA TRI.
Cross-Vertical Regulatory Divergence
Cresol is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H314, H318, H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Cresol
CAS Number
1319-77-3
DTXSID
DTXSID3024364
Synonyms
TricresolPhenol, methyl-CresylolCresolsKresolcresol, puroFenol, metil-Cresol, mixedCresol (all isomers)Cresol (mixed isomers)UN 2022 (DOT)UN 2076 (DOT)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
BiocideFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =13.94 | mg/kg bw/day | BMDL (10) | oral | Rat | ToxValDB_ATSDR_MRLs |
| - | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =0.9 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =3.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| GF3CGH8D7Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF3CGH8D7Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF3CGH8D7Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF3CGH8D7Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.026 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| =11000 | ppm | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =9 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_EPA_HWIR |
| =100 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ATSDR_MRLs |
| =100 | mg/kg/day | LOAEL | oral | Mouse (B6C3F1; F) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =0.1 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.1 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| 10000 | ppm | POLY-3 lowest dose | Dosed feed | Mouse | NTP_ICE_cancer |
| =0.0004 | mg/m3 | RfC | inhalation | Human | ToxValDB_EPA_HWIR |
| =0.6 | mg/m3 | RfC | inhalation | Human | ToxValDB_Pennsylvania_DEP_ToxValues |
| 10000 | ppm | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
| 15000 | ppm | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cresol | 215-293-2 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Cresol (mixed isomers) | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
Frequently Asked Questions
What regulatory lists include Cresol?
Cresol appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, active_ingredient; agricultural; Pesticides, and 3 more. Source: EPA CPDat.
Is Cresol used in cosmetics?
Yes, Cresol is also indexed as a cosmetic ingredient under the name Mixed Cresols. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cresol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, EPA Toxics Release Inventory, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Cresol have different safety status in cosmetics vs industrial chemicals?
Cresol is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H311, H314, H318, H412).
Is Cresol used outside industrial chemicals?
Cresol also appears in cosmetics databases.