Danger GHS07GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Cuprous oxide

Also known as: Copper oxide (Cu2O), Copper (1) oxide, Brown copper oxide, Caocobre, Caswell No. 266 (+15 more)

CAS 1317-39-1

Cuprous oxide (CAS 1317-39-1) is a chemical substance with GHS signal word Danger; key hazard signal: H332; H302; H318; H400; H410. Key regulatory status: REACH registered, 40 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Cuprous Oxide →

Cross-Vertical Regulatory Divergence

Cuprous oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H302, H318, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Cuprous oxide

CAS Number

1317-39-1

DTXSID

DTXSID0034489

Molecular Formula

2Cu.O

InChI Key

KRFJLUBVMFXRPN-UHFFFAOYSA-N

Monoisotopic Mass

141.85411

Synonyms

Copper oxide (Cu2O)Copper (1) oxideBrown copper oxideCaocobreCaswell No. 266Copper hemioxideCopper nordoxCopper oxide, redCopper sardezCopper-sandozCP Cuprous Oxide Pigment GradeCuprocide

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4; Acute Tox. 4; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1	H332; H302; H318; H400; H410	GHS07; GHS05; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Harmful if swallowed or if inhaled Causes serious eye damage Very toxic to aquatic life with long lasting effects
Short-term Effects	The substance is corrosive to the eyes. The substance is irritating to the respiratory tract and digestive tract. Inhalation of fumes may cause metal fume fever. Exposure at high levels could cause kidneys and liver impairment. The effects may be delayed.
Long-term Effects	Lungs may be affected by repeated or prolongated exposure to dust particles.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records

Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 40 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	European Commission	CPCat
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 37 of 37 studies

Value	Unit	Endpoint	Route	Species	Source
=1	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
1	unitless	EPA Classification	Inhalation	-	NTP_ICE_acute_inhalation
1	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
3	unitless	EPA classification	Dermal	Rat	NTP_ICE_acute_dermal
=3	Unitless	EPA classification	oral	Rat	NTP_ICE_acute_oral
3	unitless	EPA classification	Dermal	Rabbit	NTP_ICE_skin_irritation
=4	Unitless	EPA classification	oral	Rat (Male/Female)	NTP_ICE_acute_oral
=4	Unitless	EPA classification	oral	Rat (Male/Female)	NTP_ICE_acute_oral
T8BEA5064F	UNII	FDA UNII substance identifier	-	-	openFDA substances
T8BEA5064F	UNII	FDA UNII substance identifier	-	-	openFDA substances
T8BEA5064F	UNII	FDA UNII substance identifier	-	-	openFDA substances
T8BEA5064F	UNII	FDA UNII substance identifier	-	-	openFDA substances
=4	Unitless	GHS classification	oral	Rat	NTP_ICE_acute_oral
5	unitless	GHS classification	Dermal	Rat	NTP_ICE_acute_dermal
=5	Unitless	GHS classification	oral	Rat (Female)	NTP_ICE_acute_oral
=5	Unitless	GHS classification	oral	Rat (Male/Female)	NTP_ICE_acute_oral
>2.08	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>2000	mg/kg	LD50	Dermal	Rat	NTP_ICE_acute_dermal
>2020	mg/kg	LD50	Dermal	Rat	NTP_ICE_acute_dermal
>5000	mg/kg bw	LD50	oral	Rat (Male/Female)	NTP_ICE_acute_oral
>5050	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=61.7	mg/kg bw/day	LOAEL	oral	Chicken	ToxValDB_DOE_Wildlife_Benchmarks
=156	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=370	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
>1500	ppm	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.2	mg/m3	LOEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1	%	LOEL	dermal	Mouse	ToxValDB_ECOTOX
=3	%	LOEL	dermal	Mouse	ToxValDB_ECOTOX
>=2	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=47	mg/kg bw/day	NOAEL	oral	Chicken	ToxValDB_DOE_Wildlife_Benchmarks
=78	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=185	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1000	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.3	%	NOEL	dermal	Mouse	ToxValDB_ECOTOX
=31.9	mg/kg bw/day	NOEL	oral	Northern Bobwhite Quail	ToxValDB_EFSA
=31.9	mg/kg bw/day	NOEL	oral: feed	Bobwhite quail	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=31.9	mg/kg bw/day	NOEL	oral: feed	Bobwhite quail	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

Showing 37 of 37 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Dicopper oxide	215-270-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Cuprous oxide?

Cuprous oxide (CAS 1317-39-1) is classified under EU CLP Annex VI as Acute Tox. 4; Acute Tox. 4; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H332; H302; H318; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Cuprous oxide?

Cuprous oxide has 37 NOAEL studies in the database. The lowest reported value is 0.2 mg/m3 via inhalation in Rat. Source: ToxValDB_ECHA_IUCLID.

What regulatory lists include Cuprous oxide?

Cuprous oxide appears on 5 regulatory/inventory lists including active_ingredient; Europe; Pesticides, active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides, active_ingredient; Pesticides, and 2 more. Source: EPA CPDat.

Is Cuprous oxide used in cosmetics?

Yes, Cuprous oxide is also indexed as a cosmetic ingredient under the name Cuprous Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Cuprous oxide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Cuprous oxide have different safety status in cosmetics vs industrial chemicals?

Cuprous oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H302, H318, H400, H410).

Is Cuprous oxide used outside industrial chemicals?

Cuprous oxide also appears in cosmetics, cannabis databases.