Warning GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Cupric oxide

Also known as: Copper oxide (CuO), Copper(II) oxide, Boliden Salt K-33, Boliden-CCA Wood Preservative, Caswell No. 265 (+13 more)

CAS 1317-38-0

Cupric oxide (CAS 1317-38-0) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: REACH registered, 44 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Cupric Oxide →

Cross-Vertical Regulatory Divergence

Cupric oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields

Name

Cupric oxide

CAS Number

1317-38-0

DTXSID

DTXSID5034488

Molecular Formula

Cu.O

InChI Key

KKCXRELNMOYFLS-UHFFFAOYSA-N

Monoisotopic Mass

78.924512

Synonyms

Copper oxide (CuO)Copper(II) oxideBoliden Salt K-33Boliden-CCA Wood PreservativeCaswell No. 265CCA Type C Wood PreservativeChrome BrownCI Pigment black 15EINECS 215-269-1EPA Pesticide Chemical Code 042401Farboil Super Tropical Anti-Fouling 1260Natural tenorite

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Aquatic Acute 1; Aquatic Chronic 1	H400; H410	GHS09	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

BiocideFiller

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 44 records

List	Keyword	Source
Europe; supplements	EU	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
Canada; consumer_product; Substances in Products - Canada (4/2014)	Government of Canada	CPCat
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
=1	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
V1XJQ704R4	UNII	FDA UNII substance identifier	-	-	openFDA substances
V1XJQ704R4	UNII	FDA UNII substance identifier	-	-	openFDA substances
V1XJQ704R4	UNII	FDA UNII substance identifier	-	-	openFDA substances
V1XJQ704R4	UNII	FDA UNII substance identifier	-	-	openFDA substances
=5	mg/L	LOAEL	oral	Human	ToxValDB_Copper_Manufacturers
=156	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=370	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
>1500	ppm	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.2	mg/m3	LOEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=2	mg/m3	NOAEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=10	mg/day	NOAEL	oral	Human	ToxValDB_EFSA
=10	mg/day	NOAEL	oral: unspecified	Human	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/day	NOAEL	oral: unspecified	Human	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=78	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=185	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1000	ppm	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 17 of 17 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Copper oxide	215-269-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL cupric oxide

ChEMBL Phase

Not listed

Adverse Events

263

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Cupric oxide?

Cupric oxide (CAS 1317-38-0) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Cupric oxide?

Cupric oxide has 17 NOAEL studies in the database. The lowest reported value is 1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Cupric oxide?

Cupric oxide appears on 8 regulatory/inventory lists including Europe; supplements, active_ingredient; Europe; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 5 more. Source: EPA CPDat.

Is Cupric oxide used in cosmetics?

Yes, Cupric oxide is also indexed as a cosmetic ingredient under the name Cupric Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Cupric oxide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Cupric oxide have different safety status in cosmetics vs industrial chemicals?

Cupric oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H400, H410).

Is Cupric oxide used outside industrial chemicals?

Cupric oxide also appears in cosmetics, pharmaceutical, cannabis databases.