Warning GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

2-Chloro-6-ethylamino-4-nitrophenol

Also known as: UNII-5LIV96LADQ, 2-Chloro-6-(ethylamino)-4-nitrophenol, 6-Chloro-2-(ethylamino)-4-nitrophenol, Phenol, 2-chloro-6-(ethylamino)-4-nitro-

CAS 131657-78-8

2-Chloro-6-ethylamino-4-nitrophenol (CAS 131657-78-8) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H317; H411. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2-Chloro-6-Ethylamino-4-Nitrophenol →

SOURCE noael studies public
NOAEL studies
25
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
2-Chloro-6-ethylamino-4-nitrophenol
CAS Number
131657-78-8
DTXSID
DTXSID00157169
Molecular Formula
C8H9ClN2O3
InChI Key
CDFNUSAXZDSXKF-UHFFFAOYSA-N
Monoisotopic Mass
216.03017
Synonyms
UNII-5LIV96LADQ2-Chloro-6-(ethylamino)-4-nitrophenol6-Chloro-2-(ethylamino)-4-nitrophenolPhenol, 2-chloro-6-(ethylamino)-4-nitro-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2H302; H317; H411GHS07; GHS09Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 25 of 25 studies
ValueUnitEndpointRouteSpeciesSource
10mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
5LIV96LADQUNIIFDA UNII substance identifier--openFDA substances
5LIV96LADQUNIIFDA UNII substance identifier--openFDA substances
5LIV96LADQUNIIFDA UNII substance identifier--openFDA substances
5LIV96LADQUNIIFDA UNII substance identifier--openFDA substances
10mg/kg bw/dayLOAELoralratCOSMOS_DB
=10mg/kg bwNOAEL-ratSCCS_vision_codex
=10mg/kgNOAELoralratSCCS_vision_codex
=10mg/kg bwNOAEL-ratSCCS_vision_codex
=10mg/kgNOAELoralratSCCS_vision_codex
=10mg/kg bwNOAEL-ratSCCS_vision_codex
=10mg/kgNOAELoralratSCCS_vision_codex
=10mg/kg bwNOAEL-ratSCCS_vision_codex
=10mg/kgNOAELoralratSCCS_vision_codex
=90mg/kg bwNOAEL-ratSCCS_vision_codex
=90mg/kg bwNOAEL-ratSCCS_vision_codex
=90mg/kg bwNOAEL-ratSCCS_vision_codex
=90mg/kg bwNOAEL-ratSCCS_vision_codex
10mg/kg bwdermal absorption-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=10mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=10mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
90mg/kg bwdermal absorption-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10mg/kg bwdevelopmental toxicityoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
90mg/kg bwdevelopmental toxicity-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
90mg/kg bwdevelopmental toxicitydermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 25 of 25 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-chloro-6-(ethylamino)-4-nitrophenol411-440-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCP/1114/0718 December 2007safe3.0%secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
3.0%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Chloro-6-ethylamino-4-nitrophenol?

2-Chloro-6-ethylamino-4-nitrophenol (CAS 131657-78-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2 with signal word Warning. Hazard statements: H302; H317; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Chloro-6-ethylamino-4-nitrophenol?

2-Chloro-6-ethylamino-4-nitrophenol has 25 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include 2-Chloro-6-ethylamino-4-nitrophenol?

2-Chloro-6-ethylamino-4-nitrophenol appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 2-Chloro-6-ethylamino-4-nitrophenol used in cosmetics?

Yes, 2-Chloro-6-ethylamino-4-nitrophenol is also indexed as a cosmetic ingredient under the name 2-Chloro-6-Ethylamino-4-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Chloro-6-ethylamino-4-nitrophenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Chloro-6-ethylamino-4-nitrophenol used outside industrial chemicals?

2-Chloro-6-ethylamino-4-nitrophenol also appears in cosmetics databases.