What is the GHS hazard classification for Zinc oxide?
Zinc oxide (CAS 1314-13-2) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).
Warning
GHS09
NOAEL Data
REACH Registered
Cosmetic Ingredient
Zinc oxide
Also known as: ZnO, Oxozinc, Zinc, oxo-, Zinc oxide (ZnO), Akro-zinc bar 85 (+14 more)
CAS 1314-13-2
Zinc oxide (CAS 1314-13-2) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: REACH registered, 45 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
45
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Zinc oxide
CAS Number
1314-13-2
DTXSID
DTXSID7035016
Molecular Formula
O.Zn
InChI Key
RNWHGQJWIACOKP-UHFFFAOYSA-N
Monoisotopic Mass
79.924057
Synonyms
ZnOOxozincZinc, oxo-Zinc oxide (ZnO)Akro-zinc bar 85Akro-zinc bar 90Azodox-55TTBlanc de ZincCadox XX 78Caswell No. 920Chinese WhiteCI Pigment white 4
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Aquatic Acute 1; Aquatic Chronic 1 | H400; H410 | GHS09 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Very toxic to aquatic life with long lasting effects |
| Short-term Effects | May cause mechanical irritation to the eyes and respiratory tract. The fume is irritating to the respiratory tract. Inhalation of fumes may cause metal fume fever. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of fume. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
8 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | STEL | 10 mg/m³ | - | 10 | N |
| ACGIH | TWA | 2 mg/m³ (respirable particulate matter) [2001] | - | 2 | N |
| ACGIH | STEL | 10 mg/m³ (respirable particulate matter) [2001] | - | 10 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
| CAL/OSHA | STEL | 10 mg/m³ | - | 10 | N |
| NIOSH | IDLH | 500 mg/m³ | - | 500 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PigmentHumectantDyeUV stabilizerFillerFlame retardantAnti-static agentAdhesion/cohesion promoterBiocideProcessing aids not otherwise specifiedCatalystNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
45 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| Europe; nondetect; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Road vehicles | Danish Environmental Protection Agency | Danish EPA |
| Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | European Commission | CosIng |
| Europe; Personal care | European Commission | CosIng |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.0225 | mg/kg bw/d | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.166 | mg/kg bw/d | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.166 | mg/kg bw/d | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.166 | mg /kg bw | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.166 | mg /kg bw | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.166 | mg /kg bw | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.225 | mg/kg bw/day | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.5 | mg/kg/day | - | oral | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| 0.83 | mg/kg bw/d | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.83 | mg/kg bw/d | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.83 | mg /kg bw | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.83 | mg /kg bw | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0.9 | mg/kg/d | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1 | - | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4 | - | - | inhalation | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 20 | % | - | oral | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | - | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 90 | - | - | inhalation | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 96 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1000 | mg/kg | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1518 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3000 | ppm | - | - | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 3000 | ppm | - | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| =0.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| SOI2LOH54Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SOI2LOH54Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SOI2LOH54Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SOI2LOH54Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1.79 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =2.5 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~4.6 | mg/m3 | LEL | inhalation | Guinea Pig | ToxValDB_ECHA_IUCLID |
| =5 | mg/m3 | LEL | inhalation | Rabbit | ToxValDB_ECHA_IUCLID |
| =7.8 | mg/m3 | LEL | inhalation | Guinea Pig | ToxValDB_ECHA_IUCLID |
| =320 | mg/m3 | LEL | inhalation | Human | ToxValDB_NIOSH_IDLH |
| =600 | mg/m3 | LEL | inhalation | Human | ToxValDB_NIOSH_IDLH |
| ~731 | ppm | LEL | oral | Sheep | ToxValDB_ECHA_IUCLID |
| =125 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =320 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_DOE_Wildlife_Benchmarks |
| =0.4 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =4.8 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =31.2 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1000 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =1200 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2400 | ppm | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =6010 | ppm | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =1.96 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =7.5 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Zinc oxide | 215-222-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
4 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1518/13 | 22 April 2014 | safe with restrictions | 25% as UV-filter | Purity ≥96%; wurtzite crystal structure; median particle diameter (D50) ≥30 nm and D1 ≥20 nm; solubility <50 mg/L; no spray/inhalation products |
| SCCS/1489/12 | 18 September 2012 | safe with restrictions | up to 25% (nano and non-nano) | Limited dermal penetration confirmed; zinc ion release considered in toxicity evaluation; coatings must be demonstrated safe; particle size specifications critical for safety conclusion |
| SCCP/1200/08 | 21 January 2009 | safe (clarification) | up to 25% (non-nano particle grade; particle size >100 nm) | This opinion clarifies that only non-nano form (pigment grade, particles >100 nm) is covered; nano form required separate evaluation |
| SCCP/0892/05 | 20 September 2005 | safe (statement) | up to 25% (non-nano; particle grade sunscreen use) | Early statement confirming non-nano ZnO safe; nano form not within scope; particle size and surface characteristics need to meet specifications |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
25%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ZINC OXIDE
ChEMBL Phase
4
Adverse Events
1827
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Zinc oxide?
Zinc oxide has 100 NOAEL studies in the database. The lowest reported value is 0.0225 mg/kg bw/d via oral in human. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.
What regulatory lists include Zinc oxide?
Zinc oxide appears on 21 regulatory/inventory lists including Europe; Personal care, drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, and 18 more. Source: EPA CPDat.
What are the occupational exposure limits for Zinc oxide?
Occupational exposure limits for Zinc oxide are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Zinc oxide used in cosmetics?
Yes, Zinc oxide is also indexed as a cosmetic ingredient under the name Zinc Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Zinc oxide come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Zinc oxide used outside industrial chemicals?
Zinc oxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.