What is the NOAEL for Magnesium hydroxide?
Magnesium hydroxide has 8 NOAEL studies in the database. The lowest reported value is 21.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Magnesium hydroxide
Also known as: Magnesium hydroxide (Mg(OH)2), EINECS 215-170-3, Hydro-mag MA, Lycal 96 HSE, Magmesia hydrate (+6 more)
CAS 1309-42-8
Magnesium hydroxide (CAS 1309-42-8) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Magnesium hydroxide
CAS Number
1309-42-8
DTXSID
DTXSID4049662
Molecular Formula
Mg.2H2O
InChI Key
VTHJTEIRLNZDEV-UHFFFAOYSA-L
Monoisotopic Mass
60.006171
Synonyms
Magnesium hydroxide (Mg(OH)2)EINECS 215-170-3Hydro-mag MALycal 96 HSEMagmesia hydrateMagnesium hydroxide gelNemaliteUNII-NBZ3QY004SMagnesia, [Milk of]Mg(OH)2magnesium hydrate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
pH regulating agentAbsorbentFlame retardantBinderProcessing aids not otherwise specifiedFillerConductive agentAdhesion/cohesion promoterThickening agentDrierFlavouring and nutrientDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =21.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| NBZ3QY004S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NBZ3QY004S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NBZ3QY004S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NBZ3QY004S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Magnesium hydroxide | 215-170-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
MAGNESIUM HYDROXIDE
ChEMBL Phase
4
Adverse Events
4173
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E528 — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Magnesium hydroxide?
Magnesium hydroxide appears on 9 regulatory/inventory lists including inert_ingredient; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, Europe; supplements, and 6 more. Source: EPA CPDat.
Is Magnesium hydroxide used in cosmetics?
Yes, Magnesium hydroxide is also indexed as a cosmetic ingredient under the name Magnesium Hydroxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Magnesium hydroxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Magnesium hydroxide used outside industrial chemicals?
Magnesium hydroxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.