NOAEL Data REACH Registered Cosmetic Ingredient

Alpha-Ionone

Also known as: (3E)-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one, Cyclocitrylideneacetone, alpha-, EINECS 204-841-6, EINECS 250-293-6, FEMA No. 2594 (+8 more)

CAS 127-41-3

Alpha-Ionone (CAS 127-41-3) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Alpha-Ionone →

Cross-Vertical Regulatory Divergence

Alpha-Ionone is classified GHS Danger (H315, H317, H334) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

Alpha-Ionone

CAS Number

127-41-3

DTXSID

DTXSID0035160

Molecular Formula

C13H20O

InChI Key

UZFLPKAIBPNNCA-BQYQJAHWSA-N

Monoisotopic Mass

192.151415

Synonyms

(3E)-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-oneCyclocitrylideneacetone, alpha-EINECS 204-841-6EINECS 250-293-6FEMA No. 2594UNII-I9V075M61R(3E)-4-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-3-buten-2-on(E)-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one(E)-alpha-Iononealpha-(E)-iononealpha-Iononalpha-cyclocitrylideneacetone

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 16 of 16 studies

Value	Unit	Endpoint	Route	Species	Source
<=0.1	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=0.987	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
I9V075M61R	UNII	FDA UNII substance identifier	-	-	openFDA substances
I9V075M61R	UNII	FDA UNII substance identifier	-	-	openFDA substances
I9V075M61R	UNII	FDA UNII substance identifier	-	-	openFDA substances
I9V075M61R	UNII	FDA UNII substance identifier	-	-	openFDA substances
=250	mg/kg bw/day	LEL	oral	Chicken	ToxValDB_EFSA
=1000	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=10	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=10	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=11.1	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=11.8	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=10	mg/kg bw/day	NOEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/kg bw/day	NOEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx

Showing 16 of 16 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-(2,6,6-trimethylcyclohex-2-ene-1-yl)-but-3-ene-2-one	204-841-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ALPHA-IONONE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-0.1 mg/kg bw (1984) mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Alpha-Ionone?

Alpha-Ionone has 16 NOAEL studies in the database. The lowest reported value is 0.1 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include Alpha-Ionone?

Alpha-Ionone appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.

Is Alpha-Ionone used in cosmetics?

Yes, Alpha-Ionone is also indexed as a cosmetic ingredient under the name Alpha-Ionone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Alpha-Ionone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Alpha-Ionone have different safety status in cosmetics vs industrial chemicals?

Alpha-Ionone is classified GHS Danger (H315, H317, H334) in the chemicals database but is allowed in EU cosmetics.

Is Alpha-Ionone used outside industrial chemicals?

Alpha-Ionone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.