What is the NOAEL for Methyl abietate?
Methyl abietate has 11 NOAEL studies in the database. The lowest reported value is 7.9849846416215 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Methyl abietate
Also known as: 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, (1R,4aR,4bR,10aR)-, 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, (1R-(1alpha,4abeta,4balpha,10aalpha))-, Podocarpa-7,13-dien-15-oic acid, 13-isopropyl-, methyl ester, Methyl ester of wood rosin, 4-09-00-02176 (+7 more)
CAS 127-25-3
Methyl abietate (CAS 127-25-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Methyl abietate is classified GHS Danger (H319, H334) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Methyl abietate
CAS Number
127-25-3
DTXSID
DTXSID9048190
Molecular Formula
C21H32O2
InChI Key
OVXRPXGVKBHGQO-UYWIDEMCSA-N
Monoisotopic Mass
316.24023
Synonyms
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, (1R,4aR,4bR,10aR)-1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, (1R-(1alpha,4abeta,4balpha,10aalpha))-Podocarpa-7,13-dien-15-oic acid, 13-isopropyl-, methyl esterMethyl ester of wood rosin4-09-00-02176Abietic acid, methyl esterBRN 2702228EINECS 204-832-7Methyl 7,13-abietadien-18-oateNSC 2141UNII-BY54I7IT3LWOOD ROSIN, METHYL ESTER
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8.29473984025362 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 7.9849846416215 | uM | ACC | - | - | NTP_ICE_endocrine |
| BY54I7IT3L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BY54I7IT3L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BY54I7IT3L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BY54I7IT3L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00607 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Methyl abietate | 204-832-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
METHYL ABIETATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include Methyl abietate?
Methyl abietate appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), IFRA Transparency, consumer_product. Source: EPA CPDat.
Is Methyl abietate used in cosmetics?
Yes, Methyl abietate is also indexed as a cosmetic ingredient under the name Methyl Abietate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Methyl abietate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Methyl abietate have different safety status in cosmetics vs industrial chemicals?
Methyl abietate is classified GHS Danger (H319, H334) in the chemicals database but is allowed in EU cosmetics.
Is Methyl abietate used outside industrial chemicals?
Methyl abietate also appears in cosmetics, pharmaceutical databases.