What is the NOAEL for Pyruvic acid?
Pyruvic acid has 5 NOAEL studies in the database. The lowest reported value is 8558G7RUTR UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Pyruvic acid
Also known as: EC No.: 204-824-3, 4-03-00-01505, BRN 0506211, EINECS 204-824-3, FEMA No. 2970 (+15 more)
CAS 127-17-3
Pyruvic acid (CAS 127-17-3) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Pyruvic acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics at max 40–70% professional peel use only.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Pyruvic acid
CAS Number
127-17-3
DTXSID
DTXSID2021650
Molecular Formula
C3H4O3
InChI Key
LCTONWCANYUPML-UHFFFAOYSA-N
Monoisotopic Mass
88.016044
Synonyms
EC No.: 204-824-34-03-00-01505BRN 0506211EINECS 204-824-3FEMA No. 29702-OxopropansaeureUNII-8558G7RUTR2-Oxopropionate2-Oxopropionsaeure2-ketopropionic acidAcetylformateBTS
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
DeodorizerpH regulating agentFragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8558G7RUTR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8558G7RUTR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8558G7RUTR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8558G7RUTR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11792 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Pyruvic acid | 204-824-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
40–70% professional peel use only
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PYRUVATE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Pyruvic acid?
Pyruvic acid appears on 6 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 3 more. Source: EPA CPDat.
Is Pyruvic acid used in cosmetics?
Yes, Pyruvic acid is also indexed as a cosmetic ingredient under the name Pyruvic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Pyruvic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Pyruvic acid have different safety status in cosmetics vs industrial chemicals?
Pyruvic acid is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics at max 40–70% professional peel use only.
Is Pyruvic acid used outside industrial chemicals?
Pyruvic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.