What is the NOAEL for 4,4-Bis(4-hydroxyphenyl)valeric acid?
4,4-Bis(4-hydroxyphenyl)valeric acid has 10 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
Cosmetic Ingredient
4,4-Bis(4-hydroxyphenyl)valeric acid
Also known as: Benzenebutanoic acid, 4-hydroxy-gamma-(4-hydroxyphenyl)-gamma-methyl-, Benzenebutanoic acid, 4-hydroxy-.gamma.-(4-hydroxyphenyl)-.gamma.-methyl-, Diphenolic acid, 4,4-Bis(p-hydroxyphenyl)pentanoic acid, 4,4-Bis(4-hydroxyphenyl)pentanoic acid (+5 more)
CAS 126-00-1
4,4-Bis(4-hydroxyphenyl)valeric acid (CAS 126-00-1) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
10
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
4,4-Bis(4-hydroxyphenyl)valeric acid
CAS Number
126-00-1
DTXSID
DTXSID0022436
Molecular Formula
C17H18O4
InChI Key
VKOUCJUTMGHNOR-UHFFFAOYSA-N
Monoisotopic Mass
286.120509
Synonyms
Benzenebutanoic acid, 4-hydroxy-gamma-(4-hydroxyphenyl)-gamma-methyl-Benzenebutanoic acid, 4-hydroxy-.gamma.-(4-hydroxyphenyl)-.gamma.-methyl-Diphenolic acid4,4-Bis(p-hydroxyphenyl)pentanoic acid4,4-Bis(4-hydroxyphenyl)pentanoic acidgamma,gamma-Bis(p-hydroxyphenyl)valeric acid4,4-Bis(p-hydroxyphenyl)valeric acidEINECS 204-763-2NSC 3371UNII-2SIZ2CO5L3
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Viscosity modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 41.9411172933328 | uM | AC50 | - | - | NTP ICE endocrine |
| 18.961313331151 | uM | ACC | - | - | NTP ICE endocrine |
| - | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 2SIZ2CO5L3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2SIZ2CO5L3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2SIZ2CO5L3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2SIZ2CO5L3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.163 | fraction | Fu | - | Human | NTP ICE adme parameters |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.174 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 10 of 10 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1325931
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include 4,4-Bis(4-hydroxyphenyl)valeric acid?
4,4-Bis(4-hydroxyphenyl)valeric acid appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 4,4-Bis(4-hydroxyphenyl)valeric acid used in cosmetics?
Yes, 4,4-Bis(4-hydroxyphenyl)valeric acid is also indexed as a cosmetic ingredient under the name Diphenolic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4,4-Bis(4-hydroxyphenyl)valeric acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 4,4-Bis(4-hydroxyphenyl)valeric acid used outside industrial chemicals?
4,4-Bis(4-hydroxyphenyl)valeric acid also appears in cosmetics, pharmaceutical databases.