Also known as: Hexamethylenediamine, 1,6-Diaminohexane, 4-04-00-01320, BRN 1098307, EINECS 204-679-6 (+8 more)
CAS 124-09-4
1,6-Hexanediamine (CAS 124-09-4) is a chemical substance with GHS signal word Danger; key hazard signal: H312; H302; H335; H314. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
1,6-Hexanediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H302, H335, H314).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Corr. 1B | H312; H302; H335; H314 | GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 0.5 ppm [1990] | 0.5 | - | N |
| CAL/OSHA | TWA | 0.5 ppm (2.3 mg/m³) | 0.5 | 2.3 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.54 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| ZRA5J5B2QW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZRA5J5B2QW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZRA5J5B2QW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZRA5J5B2QW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =750 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =792 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1127 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| <3160 | mg/kg bw/day | LEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| =184 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =12.8 | mg/m3 | NOAEL | Inhalation | Rat | ToxValDB_HPVIS |
| =50 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| ~184 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~225 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 0.6 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 0.7 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 1.1 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
Showing 23 of 23 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexamethylenediamine | 204-679-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
1,6-Hexanediamine (CAS 124-09-4) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; Skin Corr. 1B with signal word Danger. Hazard statements: H312; H302; H335; H314. Source: EU CLP Annex VI (ECHA).
1,6-Hexanediamine has 23 NOAEL studies in the database. The lowest reported value is 0.54 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
1,6-Hexanediamine appears on 5 regulatory/inventory lists including Cons electronics mech appliances and machinery; Europe, Canada; pharmaceutical, drinking_water; Europe; manufacturing; plastic_additive, and 2 more. Source: EPA CPDat.
Occupational exposure limits for 1,6-Hexanediamine are set by ACGIH, CAL/OSHA. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 1,6-Hexanediamine is also indexed as a cosmetic ingredient under the name 1,6-Hexanediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
1,6-Hexanediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H312, H302, H335, H314).
1,6-Hexanediamine also appears in cosmetics, pharmaceutical databases.