What is the GHS hazard classification for Hexanedioic acid?
Hexanedioic acid (CAS 124-04-9) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexanedioic acid
Also known as: Adipic acid, 1,4-Butanedicarboxylic acid, 4-02-00-01956, BRN 1209788, EINECS 204-673-3 (+14 more)
CAS 124-04-9
Hexanedioic acid (CAS 124-04-9) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Hexanedioic acid
CAS Number
124-04-9
DTXSID
DTXSID7021605
Molecular Formula
C6H10O4
InChI Key
WNLRTRBMVRJNCN-UHFFFAOYSA-N
Monoisotopic Mass
146.057909
Synonyms
Adipic acid1,4-Butanedicarboxylic acid4-02-00-01956BRN 1209788EINECS 204-673-3FEMA No. 2011FEMA Number 2011Kyselina adipovaUNII-76A0JE0FKJ1,6-HexanedioateAdi-pureAdipate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. Inhalation of the aerosol may cause asthmatic reactions. See Notes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
2 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 5 mg/m³ [1990] | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
43 records
DeodorizerpH regulating agentFragranceFlavouring and nutrientPlasticizerProcessing aids not otherwise specifiedSoftener and conditionerOtherLeavening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =74.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 76A0JE0FKJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 76A0JE0FKJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 76A0JE0FKJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 76A0JE0FKJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >11000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 205 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| >=250 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| 263 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| >=263 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 288 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >=288 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 440 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =470 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 2400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >3750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 8000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =2 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Adipic acid | 204-673-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ADIPIC ACID
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E355 — ADI: 5 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Hexanedioic acid?
Hexanedioic acid has 24 NOAEL studies in the database. The lowest reported value is 5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
What regulatory lists include Hexanedioic acid?
Hexanedioic acid appears on 7 regulatory/inventory lists including pharmaceutical, inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, and 4 more. Source: EPA CPDat.
What are the occupational exposure limits for Hexanedioic acid?
Occupational exposure limits for Hexanedioic acid are set by ACGIH, CAL/OSHA. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Hexanedioic acid used in cosmetics?
Yes, Hexanedioic acid is also indexed as a cosmetic ingredient under the name Adipic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexanedioic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Hexanedioic acid used outside industrial chemicals?
Hexanedioic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.