What is the GHS hazard classification for Butyraldehyde?
Butyraldehyde (CAS 123-72-8) is classified under EU CLP Annex VI as Flam. Liq. 2 with signal word Danger. Hazard statements: H225. Source: EU CLP Annex VI (ECHA).
Danger
GHS02
NOAEL Data
REACH Registered
Cosmetic Ingredient
Butyraldehyde
Also known as: Butanal, 4-01-00-03229, BRN 0506061, EINECS 204-646-6, FEMA Number 2219 (+11 more)
CAS 123-72-8
Butyraldehyde (CAS 123-72-8) is a chemical substance with GHS signal word Danger; key hazard signal: H225. Key regulatory status: REACH registered, 42 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, EPA TRI.
Cross-Vertical Regulatory Divergence
Butyraldehyde is prohibited in EU cosmetics but has active industrial GHS classifications (H225).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
48
SOURCE
chemical inventory jurisdictions
Regulatory lists
42
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Butyraldehyde
CAS Number
123-72-8
DTXSID
DTXSID8021513
Molecular Formula
C4H8O
InChI Key
ZTQSAGDEMFDKMZ-UHFFFAOYSA-N
Monoisotopic Mass
72.057515
Synonyms
Butanal4-01-00-03229BRN 0506061EINECS 204-646-6FEMA Number 2219NCI-C56291UNII-H21352682A1-ButanalAldehyde butyriqueAldeide butirricaButalButalyde
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2 | H225 | GHS02 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour May be harmful if swallowed or in contact with skin Causes serious eye irritation Harmful to aquatic life |
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
42 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Road vehicles | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 48 of 48 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| H21352682A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H21352682A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H21352682A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H21352682A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.15 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.15 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.15 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.15 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| =2490 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5890 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~3030 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| ~4570 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| ~16600 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =56034.4 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =368.647 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =5898.35 | mg/m3 | LOAEC | inhalation | Dog | ToxValDB_ECHA_IUCLID |
| =75 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =345.054 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| 80 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 80 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 80 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 80 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| =151.293 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =5898.35 | mg/m3 | NOAEC | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =51.3 | ppm | NOAEL | - | Rat | ToxValDB_TX_TCEQ |
| =150 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =625 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =678.311 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_TX_TCEQ |
| =27.0145 | mg/m3 | NOAEL (HEC ADJ) | inhalation | Rat | ToxValDB_TX_TCEQ |
| =625 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 18 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 18 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 18 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 18 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 48 of 48 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butyraldehyde | 204-646-6 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Butyraldehyde | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BUTANAL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Butyraldehyde?
Butyraldehyde has 48 NOAEL studies in the database. The lowest reported value is 3 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
What regulatory lists include Butyraldehyde?
Butyraldehyde appears on 14 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, air; Cons electronics mech appliances and machinery; detected; emissions; Europe, Cons electronics mech appliances and machinery; detected; emissions; Europe, and 11 more. Source: EPA CPDat.
Is Butyraldehyde used in cosmetics?
Yes, Butyraldehyde is also indexed as a cosmetic ingredient under the name Butyraldehyde. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Butyraldehyde come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Butyraldehyde have different safety status in cosmetics vs industrial chemicals?
Butyraldehyde is prohibited in EU cosmetics but has active industrial GHS classifications (H225).
Is Butyraldehyde used outside industrial chemicals?
Butyraldehyde also appears in cosmetics, pharmaceutical, cannabis databases.