What is the NOAEL for Ethyl hexanoate?
Ethyl hexanoate has 10 NOAEL studies in the database. The lowest reported value is FLO6YR1SHT UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl hexanoate
Also known as: Acetic acid, butyl-, ethyl ester, BRN 1701293, EINECS 204-640-3, FEMA No. 2439, UNII-FLO6YR1SHT (+13 more)
CAS 123-66-0
Ethyl hexanoate (CAS 123-66-0) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
10
SOURCE
Chemical inventory jurisdictions
Regulatory lists
13
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Ethyl hexanoate
CAS Number
123-66-0
DTXSID
DTXSID3021980
Molecular Formula
C8H16O2
InChI Key
SHZIWNPUGXLXDT-UHFFFAOYSA-N
Monoisotopic Mass
144.11503
Synonyms
Acetic acid, butyl-, ethyl esterBRN 1701293EINECS 204-640-3FEMA No. 2439UNII-FLO6YR1SHTCaproic acid ethylesterCapronic ether absoluteEthyl N-hexanoateEthyl butyl acetateEthyl butyl acetate (dot)Ethyl ester of hexanoic acidEthyl hexanoate (caproate)
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
FragranceSolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| FLO6YR1SHT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FLO6YR1SHT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FLO6YR1SHT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FLO6YR1SHT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 350 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl hexanoate | 204-640-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl hexanoate?
Ethyl hexanoate appears on 12 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Australia; Food and drug - smoking-related products, IFRA Transparency, and 9 more. Source: EPA CPDat.
Is Ethyl hexanoate used in cosmetics?
Yes, Ethyl hexanoate is also indexed as a cosmetic ingredient under the name Ethyl Hexanoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl hexanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethyl hexanoate used outside industrial chemicals?
Ethyl hexanoate also appears in cosmetics, food safety, cannabis databases.